Thyroid dysfunction is the common endocrine disorder and females are more affected than males. The aim of this study was to assess the serum thyroid hormones level in premenopausal and postmenopausal females with thyroid dysfunction and observed the effect of thyroid dysfunction on body weight and menstrual regularity. Total 91 female subjects were included in the study. Serum thyroid hormone levels of TSH, FT3 and FT4 were assessed by ELISA technique. It was concluded from the present study that serum TSH levels were significantly higher in premenopausal and postmenopausal hypothyroid females as compared to the control group (P<0.01). In hyperthyroid premenopausal females serum TSH level was significantly lower from the control group (P<0.01). Serum FT3 level was significantly higher in hyperthyroid premenopausal and postmenopausal females as compared to control group (P<0.01). In this study, 80% of premenopausal hypothyroid females and 65% of hyperthyroid females complained about menstrual irregularities, this percentage is high as compared to control subjects which is 20% (P<0.01). Inverse negative correlation was observed between TSH, T3, TSH, and T 4, whereas positive correlation was observed between T3 and T 4. Thyroid dysfunction can lead to menstrual irregularities and infertility.

The aim of this study was to investigate thyroid hormones (T 3 , T 4) and its regulatory hormone (TSH) levels in obese women with sedentary life style. The studied population consists of 180 female subjects of age group 20-45 years. The study was carried out on female population of Allama Iqbal Town, Samanabad, and Lahore College for Women University, Lahore. The subjects were divided into three categories on the basis of body mass index (BMI): normal weight subjects (n=60) overweight subjects (n=60) and obese subjects (n=60) according to Asian criteria. Thyroid hormone levels were assessed by commercially available Enzyme linked immunosorbent assay (ELISA) kits. Statistical analysis was done by SPSS (version 13.0). It is concluded that although thyroid function was in clinically normal range in all the subjects but when comparison was done between the groups using one way ANOVA serum T 3 concentration was significantly low in obese and overweight subjects in comparison with normal weight subjects (p≤0.005). Serum T 4 concentration was significantly lower in overweight and obese subjects in comparison to normal weight (p≤0.005). Serum TSH concentration was significantly higher in obese in comparison with normal weight (p≤0.005) while it was non significantly higher in overweight subjects (p≥0.05).