Hepatitis B and C virus (HBV/HCV) infections are serious global health problems. Shaving by barbers has been identified as the key risk factor for spread of HBV. We conducted a cross-sectional survey of barbers in Hyderabad city, Pakistan in 2007 to establish their knowledge and attitudes to the risk of HBV and HCV transmission and their working patterns. Observations showed that 96.2% washed razors with antiseptic after each client and 95.7% used a new blade with new clients. However, knowledge about the diseases and modes of transmission were poor and only 36.6% knew that hepatitis can be transmitted via shaving instruments. Only 3.2% of 186 barbers were vaccinated against HBV. Strategies are needed for raising awareness and regulations of barbers' practices.
Antibiotics have revolutionized the treatment of bacterial infections. However,
it is widely held that there is underinvestment in antibiotics research and
development relative to the socially optimal level for a number of reasons. In
this article, we discuss whether existing health technology assessment
procedures recognize the full economic and societal value of new antibiotics to
patients and society when making reimbursement decisions. We present three
recommendations for modelling the unique attributes of value that are specific
to novel antibiotics. We find, based on a review of the literature, that some of
the value elements proposed by our framework have previously been discussed
qualitatively by health technology assessment bodies when evaluating
antibiotics, but are not yet formally captured via modelling. We present a
worked example to show how it may be possible to capture these dimensions of
value in a more quantitative manner. We conclude by answering the question of
the title as follows: the unique attributes of novel antibiotics
should be considered in reimbursement decision making, in a
way that captures the full range of benefits these important technologies bring
to patients, health care systems, and society.
The need for new "pull" incentives to stimulate antibiotic R&D is widely recognized. Due to the global diversity of health systems, combined with different challenges faced by antibiotics used in different types of healthcare settings, there is no one-size-fits-all solution. Instead, different "pull" incentives should be tailored to local contexts, priorities, and antibiotic types. Policymakers and industry should collaborate to identify appropriate solutions at the local, regional, and global levels.
The Diagnosis Confirmation Model (DCM) includes a dual-pricing mechanism designed to support value-based pricing of novel antibiotics while improving the alignment of financial incentives with their optimal use in patients at high risk of drug-resistant infections. DCM is a market-based model and complementary to delinked models. Policymakers interested in stimulating antibiotic innovation could consider tailoring the DCM to their reimbursement systems and incorporating it into the suite of incentives to improve the economics of antibiotics.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.