Aims and Objectives: 1) To compare safety and operative complications in abdominal versus vaginal routes of hysterectomy. 2) To compare the length of stay in hospital with regard to the route of hysterectomy.  3) To compare the postoperative morbidity in abdominal versus vaginal routes of hysterectomy. Methodology: The study is a prospective study conducted in the department of obstetrics and Gynecology. Civil hospital, Ahmedabad between the period of Jan 2016 to 2017. Of 100 patients. Fifty patients who underwent hysterectomy by vaginal route are taken as study group A, and the remaining 50 patients who underwent by the abdominal route are taken as study group B. Inclusion criteria for hysterectomy are: 1. Uterine benign diseases such as fibroids, adenomyosis and CIN. 2. Gynecological symptoms that justified total hysterectomy. 3. Patients without fertility requirement. 4. Patients who gave informed consent to participate. Exclusion criteria for hysterectomy are: 1. Uterine size more than 12 week of gravid uterus. 2. Highly restricted uterine mobility. 3. Malignancy 4. Patient with fertility requirement. Results: Majority of women undergoing hysterectomy were in age group of 30-50 years; postmenopausal age group women were less;13 NDVH and 5 in AH. Majority of the women were multipara in both age groups. Menorrhagia was found to be major indication with 42 in NDVH and 40 in AH. There is much significant difference in the postoperative pain in both groups with less in NDVH group. There is not much significant difference in blood loss in both the groups. Postoperative complications were more with AH. Conclusion: Thus, it can be concluded that NDVH is feasible, safe and provide more patient comfort without increasing the duration of surgery and other post –operative complications.