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A paper spray ion source was combined with a drift tube operating at ambient pressure for mobility measurements of ions derived from pharmaceutical solutions. Paper spray ionization with solvent alone resulted in a mixture of ions convolved to a single peak with a reduced mobility of 2.19 cm 2 /Vs in the mobility spectrum. These were mass-identified principally as m/z 157, (MeOH) 2 (HCOOH) 2 H + and m/z 129, (MeOH) 4 (H 2 O) H + while pharmaceuticals with nitrogen bases formed MH + product ions. The duration of response was governed by the volume of liquid added to the paper source and was limited by evaporation of solvent in gas at 58°C venting the drift tube. Quantitative variation was attributed in part to morphologic changes in the tip of the paper spray source. This was associated with mass flow in the electrical discharge and not due alone to cycles of wetting and drying of the paper. Mobility spectra of chlorpromazine in urine, exhibited a single product ion peak and linear response was 30 to 500 ng with an estimated limit of detection of 1.5 ng. Ion flux could be prolonged by continuous addition of liquid and findings portend a combination of paper spray ionization IMS with paper chromatography.

An ink-jet microchip interface between the continuous liquid flow and flame-ionization detector (FID) for gas chromatography (GC) has been developed. An ink-jet microchip for a conventional recorder was modified for the interface. When the interface was used for a flow-injection analysis (FIA) system with FID, 3.3 ng of the detection limit (S/N = 3) of ethanol in water was performed.

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