Background: Lu/B-CAM is a specific receptor for laminin ␣5, a subunit of laminin-511 (LM-511) that is a major component of basement membranes. Results: Expression of Lu/B-CAM promotes tumor cell migration on LM-511 rather than cell attachment. Conclusion: Tumor cell migration on LM-511 requires that Lu/B-CAM competitively weakens cell attachment through integrins. Significance: The competitive interaction of the laminin receptors may provide a balance between static and migratory cell behaviors.

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