Sporadic parathyroid carcinomas frequently have HRPT2 mutations that are likely to be of pathogenetic importance. Certain patients with apparently sporadic parathyroid carcinoma carry germ-line mutations in HRPT2 and may have the HPT-JT syndrome or a phenotypic variant.

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The low energy particle (LEP) instrument onboard GEOTAIL is designed to make comprehensive observations of plasma and energetic electrons and ions with fine temporal resolution in the terrestrial magnetosphere (mainly magnetotail) and in the interplanetary medium. It consists of three units of sensors (LEP-EA, LEP-SW and LEP-MS) and a common electronics (LEP-E). The Energy-per-charge Analyzers (EA) measure three-dimensional velocity distributions of electrons (with EA-e) and ions (with EA-i), simultaneously and separately, over the. energy-per-charge range of several eV/q to 43 keV/q. Emphasis in the EA design is laid on the large geometrical factor to measure tenuous plasma in the magnetotail with sufficient counting statistics in the high-time-resolution measurement. On the other hand, the Solar Wind ion analyzer (SW) has smaller geometrical factor, but fine angular and energy resolutions, to measure energy-per-charge spectra of the solar wind ions. In both EA and S W sensors, the complete three-dimensional velocity distributions can only be obtained in a period of four spins, while the velocity moments up to the third order are calculated onboard every spin period (nominally, 3 sec). The energetic-ion Mass Spectrometer (MS) can provide three-dimensional determinations of the ion composition. In this paper, we describe the instrumentation and present some examples of the inflight measurements.

Our results show there are large differences in GEP-NETs between Japan and Western nations, primarily due to differences in the presence of MEN-1 in NF-PETs and the location, symptomatic status, and prevalence of malignancy in GI-NETs.

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. However, to our best knowledge, at least 163 cases of functioning parathyroid carcinoma appeared in the English literature from 1981 to 1989. We summarize the available information obtained from the reports of those patients and compare it with previous descriptions of the disease. The etiology of parathyroid carcinoma is usually obscure, but the possibility of a radiation-induced malignant change in the parathyroid gland became evident in a few patients. Clinical manifestations, including age, sex, symptoms, and biochemical findings in this review were comparable to those in previous reviews. Noninvasive localization studies such as ultrasonography may offer a diagnostic clue to parathyroid carcinoma. Measurement of DNA content is a useful adjunct for making the histologic diagnosis of parathyroid carcinoma and prediction of the clinical outcome. Since the initial operation offers the best chance for cure, pre-operative suspicion and intra-operative recognition of the parathyroid cancer are essential. The initial operation should be en bloc resection of the tumor, avoiding rupture of the tumor capsule and spillage of tumor cells. As parathyroid carcinoma is a slow-growing but tenacious malignancy, repeated resection of local recurrent tumors or even distant metastases is effective for palliation of recurrent hypercalcemia and occasional cure. When hypercalcemia is refractory to surgical therapy or no recurrent tumor can be identified, other modalities of therapy must be considered. New drugs to control hypercalcemia by inhibiting bone resorption may hold promise in patients with recurrent parathyroid carcinoma.