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Infective endocarditis (IE) is one of the most common diseases occurring in patients with valvular heart disease (VHD). One of the causes of IE is bacteremia caused by oral jaw infections, including medication‐related osteonecrosis of the jaw (MRONJ) and oral surgery. We performed an extensive surgery for MRONJ prior to aortic valve replacement with severe aortic stenosis (SAS) for IE prevention. In patients with SAS and MRONJ who are being suggested a surgery on standby for VHD, a prior extensive surgery for MRONJ should be considered to prevent the risk of IE.

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As society ages and inspection technology develops, the incidence of secondary malignancies has increased. Esophageal and gastric cancers are common for primary tumors of oral secondary malignancies, but, on the otherhand, ML (malignant lymphomas) are rare. We report here two cases of mandibular SCC (squamous cell carcinoma) complicated with ML as metachronous secondary malignancies. In both cases, oral SCCs were aggressive and the clinical courses were rapid. Case 1 was a 62-year-old man who had a past history of CLL (chronic lymphocytic leukemia) /SLL (small lymphocytic lymphoma) and developed oral SCC. Though he had a surgical resection after chemoradiotherapy, SCC recurred just two months post operation. Case 2 was an 83-year-old man who developed oral SCC during treatment for Epstein-Barr Virus(EBV)-positive DLBCL (diffuse large B-celllymphoma) of the elderly. He discontinued chemotherapy and he had an operation for oral SCC. Etoposide was resumed for exacerbation of EBV-positive DLBCL of the elderly ; he is alive without any relapse of oral SCC. Aggressive clinical features of secondary oral malignancies are considered to be closely related to a long-term immunosuppressive state due to ML and chemotherapy.