No abstract

: Bony atrophy around the components following total knee arthroplasty TKA is often observed by radiography. To investigate the underlying cause of this incidence, we sought to quantitatively evaluate postoperative bone changes around the total knee components using dual-energy X-ray absorptiometry DXA over time. A retrospective study was conducted to compare bone mineral density BMD around the components in 22 patients pre-operatively and at 1, 3, 6, 12, and 24 months after cementless TKA for the treatment of osteoarthritis. In the coronal view, the medial tibia showed that a signi cant decrease in BMD at 12 months compared with 1 month after surgery P 0.05 , while the sagittal view showed that a signi cant decrease in BMD only at the anterior femoral condyle at 24 months compared with 1 month postoperatively P 0.05 . TKA improved the leg alignment and load-bearing axis in all patients, but we found that BMD tended to decrease on the medial side of the tibia and the anterior femoral condyle area over time following surgery. Our results suggest that recreating proper valgus alignment of the knee joint provides physiological balancing and condition. A larger prospective study is warranted.

ObjectiveVarious markers of bone metabolism are used to help develop treatment plans for osteoporosis or for assessing therapeutic effects of osteoporosis medications. Many investigations have examined the effects of various bone metabolism markers 1-3 , but few have examined correlations across multiple types of bone metabolism markers. We investigated correlations Relationships between Markers of Bone Metabolism Used in the Treatment of OsteoporosisTakashi NAGAI, Keizo SAKAMOTO, Kennichi MUNECHIKA, Masayori FUJITA, Naoto TSUCHIYA, Takashi SHIBUKI and Katsunori INAGAKI Abstract : Various markers of bone metabolism are used in the treatment of osteoporosis as they can help assess the condition of bony tissue/bone metabolism and can help predict the likelihood of fractures and bone loss in the near future. We investigated correlations between various bone metabolism markers to ascertain which could be used as a universal marker of bone metabolism and its associated care. Subjects comprised 144 female patients treated for osteoporosis at this facility between January and December 2009, in whom the following bone metabolism markers were measured on the same day : BAP, urine NTX, OC, ucOC, and TRACP-5b. The mean age of the subjects was 71.2 years. All subjects were analyzed as an entire group total group , and subjects were also divided into 2 groups and analyzed based on whether they were using an osteoporosis drug or not. Subjects currently being treated were included in the treated group n=113 ; mean age : 71.9 years . Subjects with no treatment experience were included in the untreated group n=31 ; mean age : 68.6 years . In the total group and treated group, signi cant correlations were revealed between BAP, urine NTX, OC, ucOC, and TRACP-5b. In the untreated group, no correlation was observed between BAP and ucOC, but correlations between BAP, urine NTX, OC, ucOC, and TRACP-5b were observed. ucOC is a marker of bone metabolism, and is also an indicator of the state of vitamin K intake. Based on the correlations with both bone resorption markers and osteoplastic markers found in this study, ucOC was found to be the best universal marker to use in the clinical setting.