Introduction: Global climate change is already affecting the health, living conditions, and livelihoods of people on all continents. According to many researchers, the deterioration of the patient's condition is manifested after a solar flare, with the onset of a magnetic storm. Aim: The aim of the article is to study the influence of heliogeophysical factors on the development and outcomes of myocardial infarction. Material and methods: Using data on the effect of space weather on a person from France, Germany, China, Israel, Lithuania, Georgia, a number of Russian clinics – wherever patients with ischemic heart disease were observed, during magnetic storms. Results and discussion: An in-depth study of mortality from myocardial infarction in various climatic and geographical regions showed the dependence of the number of deaths on the season of the year and sharp fluctuations in individual meteorological parameters of the weather to a much greater extent in the year of solar activity. Conclusions: It was found that patients with cardiovascular diseases (CVD) are especially susceptible to heliogeophysical disturbances. The number and severity of CVD depend on many environmental factors (atmospheric pressure, air temperature, cloud amount, ionisation, radiation regime, etc.), a reliable and stable relationship of CVD is revealed with chromospheric flares and geomagnetic storms.