Psoriasis is one of the most common chronic inflammatory skin disorders, with cutaneous and systemic manifestations and substantial negative effects on affected patients' quality of life. [1] MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. [2] Recent studies have revealed that interactions between miRNAs and their targets play critical roles in regulating distinct signalling pathways during skin differentiation. [3,4] Evidence is rapidly accumulating for the roles of miRNAs in the pathogenesis of inflammatory skin disorders. [5][6][7] In previous studies, others and we have shown that miR-197-3p (hereafter named miR-197) expression is downregulated in the psoriatic lesions compared to normal or uninvolved psoriatic skin. [6,8] Moreover, we showed that miR-197 modulates IL-22 and IL-17 signalling in normal keratinocytes (KC). Specifically, we found that both IL-22 and IL-17 activated the transcription of miR-197, and miR-197 targets and inhibits the expression of both the IL22RA1 subunit of