This article highlights the significant development in stereoselective domino reactions involving 1,6-addition as a crucial step.

Despite the persistent presence of medium-sized (seven- to nine-membered) scaffolds in natural products and biologically active molecules, their asymmetric syntheses have always been considered a formidable task; therefore remained underdeveloped...

Enantioselective syntheses of spirocyclohexenone-isobenzofuranones have been achieved through an organocatalyzed sulfa-Michael desymmetrization reaction. A cinchona-derived squaramide effectively promotes the desymmetrization of spirocyclic 2,5-cyclohexadienone isobenzofuranones via the controlled addition of various...

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