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A modified procedure for the synthesis of cucurbit[6]uril on the kilogram scale was elaborated. The procedure includes reaction of glycoluril with paraformaldehyde in the minimal amount of concentrated sulfuric acid, filtration of the product directly from the reaction mixture, and workup by dissolution and reprecipitation of the product in water, with a yield of up to 65%. The modifications made the procedure more environmentally friendly and suitable for large-scale synthesis.

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