Regular manipulations with central venous catheters (CVC) are associated with the risk of medical adhesive-related skin injury (MARSI) and infectious complications. Traditionally, alcohol-containing anti-adhesives are used to remove film dressings, but they may cause skin toxic effects. Meanwhile, the silicone-based anti-adhesives are successfully used in clinical practice, especially in abdominal surgery. In 2021-2022, hematopoietic stem cell transplantation (HSCT) recipients (n=46) with haematology diseases participated in comparative study. The control group (n=26) consisted of patients who used alcohol-containing solution (Ekobriz, Mir Dezinfektsii, Russia) for CVC care, and the comparison group (n=20) was treated with silicone-based spray (Niltac, Convatec,