Alopecia areata (AA) is an autoimmune disease resulting in nonscarring hair loss. Topical, intralesional, and systemic agents are available. 1 Intralesional corticosteroids (ILCs) may be used in patients above 10 years of age with <50% scalp involvement. 2 Other previously tried modalities with success include topical immunomodulators 3 and chemical peeling using phenol and lactic acid. 4,5 Trichloroacetic acid (TCA) is a chemical peeling agent that precipitates epidermal proteins and destructs the upper dermis. 6 TCA 35% was tried with successful results in treating patchy alopecia areata. The proposed mechanism of action was through stimulating growth factors and cytokines during the wound-healing process. 7 The aim of the current work was to compare clinically and trichoscopically the efficacy of this peeling agent for the treatment of patchy alopecia areata with ILCs.
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