ObjectiveTo investigate the relationship between amyloid burden and frequency of existing and incidence of new neuropsychiatric symptoms (NPS) in elderly with and without cognitive decline.Methods275 cognitively normal controls (NC), 100 subjective memory complaint (SMC), 559 mild cognitive impairment (MCI) and 143 Alzheimer’s disease dementia subjects from the Alzheimer’s Disease Neuroimaging Initiative received (18F)-florbetapir positron emission tomography (PET) scans. Yearly neuropsychiatric inventory (Neuropsychiatric Inventory (NPI)/NPI-Questionnaire) data were collected from the study partners at each visit. Mean standard uptake volume ratios (SUVR) normalised to whole cerebellum were obtained. Positive amyloid PET scan was defined as mean SUVR ≥1.17. Fisher’s exact test was used to compare frequency and incidence between amyloid positive and amyloid negative subjects. Survival analyses were used to estimate of neuropsychiatric symptoms (NPS) between amyloid positive and amyloid negative subjects. Survival analyses were used to estimate hazard ratios for developing the most common NPS by amyloid status.ResultsNo differences in NPS frequency were seen between amyloid positive and amyloid negative NC, SMC, MCI or dementia groups. MCI subjects with amyloid pathology however tended to have greater frequency x severity (FxS) of anxiety, hallucinations, delusions, apathy, disinhibition, irritability, aberrant motor behavior, and appetite, but not agitation, depression, night-time disturbances, or elation. MCI subjects with amyloid pathology were at greater risk for developing apathy, anxiety and agitation over time. Baseline presence of agitation and apathy and new onset agitation, irritability and apathy predicted faster conversion to dementia among MCI subjects.ConclusionsAmyloid pathology is associated with greater rate of development of new NPS in MCI. Anxiety and delusions are significant predictors of amyloid pathology. Agitation, irritability and apathy are significant predictors for conversion from MCI to dementia.

Abstract Objective To evaluate the feasibility, acceptability, and preliminary efficacy of a mind–body intervention for moderate to severe primary dysmenorrhea (PD). Design Open trial (single arm). Setting Academic medical school. Subjects A total of 20 young adult women with moderate to severe primary dysmenorrhea were included across four separate intervention groups. Methods All participants received five 90-minute sessions of a mind–body intervention and completed self-report measures of menstrual pain, depression, anxiety, somatization, and pain catastrophizing at baseline, post-treatment, and at one-, two-, three-, and 12-month follow-up. Self-report of medication use and use of skills learned during the intervention were also collected at all follow-up points. Results Participants reported significantly lower menstrual pain over time compared with baseline. No changes in anxiety, depression, or somatization were observed, although pain catastrophizing improved over time. Changes in menstrual pain were not associated with changes in medication use or reported use of skills. Conclusions A mind–body intervention is a promising nondrug intervention for primary dysmenorrhea, and future research should focus on testing the intervention further as part of a randomized clinical trial.

Background: College campuses have policies restricting smoking/vaping on campus. Previous studies involving mostly European-American students showed smoking prevalence declines following implementation of such policies. Objective: To evaluate a social media campaign promotive of stronger campus support for an existing campus no-smoking/no-vaping policy where most (75%) of the undergraduates were non-European-American. A demographically comparable university served as a no-intervention control. Participants: Target was 200 random intercept surveys at each university during fall 2016, spring 2017. Of 800 respondents, 681 were undergraduates. Methods: Baseline and post-intervention surveys assessed awareness of and support for campuswide smoke-free/vape-free policies. Staged smoke-free/vape-free policy violations assessed students' propensity to intervene in support of the policy. Results: Respondent support for the no-smoking/no-vaping policy did not change. Conclusions: The social media campaign and Policy Ambassadors program did not increase support for the campus no-smoking/no-vaping policy. Most (90%) respondents agreed that the campus no-smoking/no-vaping policy was important for public health.

Objectives: To compare the effectiveness of a psychoeducational group program and conventional treatment versus individual conventional care in patients with a mild/moderate depression disorder in urban primary healthcare centers (PHCC). Methods: Design: randomized controlled trial of two groups. Sample: patients aged 20 years attended in 13 PHCC, identified by general practitioners and nurses with diagnosis of mid/moderate depression disorder (BDI scale) between December 2008 and April 2009. The intervention group received a psycoeducational group program (12 weeks, two nurses). The program provided health education about the illness, pharmacological treatment, diet, physical exercise, problem solving, and cognitive-behavioral therapy. The control group received conventional care. The evolution of patients is monitoring up to 1 year after the inclusion by an individual interview (baseline and 3, 6, 9 months). The battery of assessment included: Sociodemographic, BDI and EuroQol-5D questionnaires. Results: 241 patients (126 intervention Group (IG); 115 control Group (CG)), 217 women (53% IG and 47%CG) with a mean age of 54, 11 (SD=12,656). 92% Spanish. 45% married. Academic level: 76, 5 % study and 13,5% non-study.