Abstract:Tumors on the epidermis of the trunk in 2 dogs (8-year-old, male Pomeranian dog and 9-year-old, female mongrel dog) were diagnosed as seborrheic keratosis. Histopathogical examination revealed that the epidermis was acanthotic and broad with a proliferation of the basaloid cells, arranged in glandular structures or cords that interconnected or surrounded the irregular keratin-filled cysts. The prominent hyperpigmantation was observed in the basal layer, and there was pigment clumping in the cysts. The histopathologic findings observed in the dogs are consistent with those in the acanthotic variant of seborrheic keratosis in humans.

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An open study was carried out for dermo-cosmetic evaluation of a spot-on formulation composed of essential oils and polyunsaturated fatty acids. The spot-on formulation was used on animals as sole therapy, or concurrent therapy with previous treatments which did not affect the evaluation of the test product. Each animal was treated with the spot-on by application of one pipette per week (total of 4 applications). In all

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Twelve-year-old spayed female mixed-breed dog presented with a swollen lip.Histopathologic examination of the lesion revealed granulomatous inflamation with mixed cell infiltration at the dermis, but no infectious agents. This lesion was diagnosed as sterile granulomatous inflammation, and was completely improved with minocycline as an immunomodulatory drug. It is considered that this swollen lip might be equivalent to granulomatous cheilitis in humans. Jpn J Vet Dermatol 2004, 10 (3): 125-127) (