Abstract-Action potential duration (APD) restitution properties and repolarization alternans are thought to be important arrhythmogenic factors. We investigated the role of intracellular calcium (Ca 2ϩ i ) cycling in regulating APD restitution slope and repolarization (APD) alternans in patch-clamped rabbit ventricular myocytes at 34 to 36°C, using the perforated or ruptured patch clamp techniques with Fura-2-AM to record Ca 2ϩ i . When APD restitution was measured by either the standard extrastimulus (S1S2) method or the dynamic rapid pacing method, the maximum APD restitution slope exceeded 1 by both methods, but was more shallow with the dynamic method. These differences were associated with greater Ca 2ϩ i accumulation during dynamic pacing. The onset of APD alternans occurred at diastolic intervals at which the APD restitution slope was significantly Ͻ1 and was abolished by suppressing sarcoplasmic reticulum (SR) Ca

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Attribute-based communication provides a novel mechanism to dynamically select groups of communicating entities by relying on predicates over their exposed attributes. In this paper, we embed the basic primitives for attribute-based communication into the functional concurrent language Erlang to obtain what we call AErlang, for attribute Erlang. To evaluate our prototype in terms of performance overhead and scalability we consider solutions of the Stable Marriage Problem based on predicates over attributes and on the classical preference lists, and use them to compare the runtime performance of AErlang with those of Erlang and X10. The outcome of the comparison shows that the overhead introduced by the new communication primitives is acceptable, and our prototype can compete performance-wise with an ad-hoc parallel solution in X10.

Attribute-based communication provides a novel mechanism to dynamically select groups of communicating entities by relying on predicates over their exposed attributes. In this paper, we embed the basic primitives for attribute-based communication into the functional concurrent language Erlang to obtain what we call AErlang, for attribute Erlang. To evaluate our prototype in terms of performance overhead and scalability we consider solutions of the Stable Marriage Problem based on predicates over attributes and on the classical preference lists, and use them to compare the runtime performance of AErlang with those of Erlang and X10. The outcome of the comparison shows that the overhead introduced by the new communication primitives is acceptable, and our prototype can compete performance-wise with an ad-hoc parallel solution in X10.

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