Introduction:Incidence of Rh negative pregnancy in western countries is 15%, but in India it varies from 3% to 5.7%. It is a high risk pregnancy, as it may cause antigen-antibody reaction and haemolysis. However, it can be prevented by adequate measures. Aims and objectives: To determine feto-outcome in Rh negative pregnant women. Materials and methods: Across sectional study was carried out in the department of Obstetrics & Gynaecology and Paediatrics, Regional Institute of Medical Sciences, Imphal, Manipur for the duration of 2 years. The total of 38 Rh negative pregnant women were included in the study after applying inclusion and exclusion criteria. Results: In the present study among 38 patients, 31.6% were delivered through Elective LSCS, 26.31% were vaginally delivered and 21.1% were Emergency LSCS. Among 38 patients, 5.3% were preterm birth, 92.1% were term birth and 2.6% were post term birth. In this study, 7.9% of patients in the study group were indirect coomb' test (ICT) positive, 92% were ICT negative. Out of 38 patients, 20 were booked who received antenatal anti-D prophylaxis in contrast to 18 unbooked patients. 35 out of 38 patients received post-natal prophylaxis with 300 mcg anti-D. Perinatal outcome in 38 patients was 73.7% were healthy, NICU admission were 15.8%, intrauterine death (IUD) were 5.3% and 2.6% were neonatal death. The conventional treatment measures are appropriate hydration, phototherapy and exchange transfusion. Conclusions: Rh haemolytic disease of the new-born forms common and preventable cause of maternal and perinatal morbidity. Anti-D IgG administration and proper fetal and neonatal monitoring when required decreases the burden of disease

Background: Preterm birth is the leading cause of infant morbidity and mortality in the world. It affects not only the immediate neonatal period but also affects infancy, childhood and even adulthood. The aim of the study was to ascertain the causes and outcome of preterm labor and delivery and also the neonatal outcome.Methods: A hospital based cross-sectional study was conducted among patients who entered the third trimester of pregnancy and diagnosed as a case of threatened preterm labor or preterm labor from September 2017 to August 2019 in the department of obstetrics & gynaecology in collaboration with department of paediatrics, Regional institute of Medical Sciences, Imphal. Detailed clinical history and socio-demographic profile were recorded in pre-designed proforma. General physical examination and systemic examination and obstetrical examination was carried out for the participants.Results: Out of 918 preterm births 88.9% of neonates between the gestation period 28 weeks and <32 weeks were admitted to NICU. 48.8% of the neonates were having low birth weight. 23.8% of neonates required NICU admission and the most common neonatal complications were sepsis (5.2%), asphyxia (4%), jaundice (4%) and hyaline membrane disease (1.7%). Apgar score significantly improved as the period of gestation increased at 5 minute and 10 minutes (p=0.006 and p<0.001 respectively). The overall mortality among preterm births was 8.1% and only 3.7% neonatal deaths were seen in gestational age 34 weeks to <37 weeks, whereas 24.1% and 22.2% mortality were seen in 32 weeks to <34 weeks and 28 weeks to <32 weeks of gestation (p=<0.001).Conclusions: Preterm infants are at high risk for overall morbidity and mortality compared with term infants. Proper antenatal care, clinical suspicion, early detection and correction of risk factors, institutional delivery and good neonatal care facilities can improve the outcome of preterm labour.

Background: PPH is the most common cause of maternal death worldwide. Risk factors for PPH include grand multiparity and multiple gestation. However, PPH may occur in women without identifiable clinical or historical risk factors. It is therefore recommended that active management of the third stage of labour be offered to all women during childbirth, whenever a skilled provider is assisting with the delivery. The aim of our study is to determine the efficacy of tranexamic acid in decreasing blood loss in elective LSCS. Materials: A quasi experimental study was done in 312 pregnant women undergoing elective LSCS in the Department of Obstetrics and Gynaecology, at a tertiary health teaching centre RIMS, Imphal, Manipur from September 2019 to November 2021. Ethical clearance was obtained from Research ethics Board to carry out the study. Data were entered in IBM SPSS version 21 software for Windows. Results: The total of 312 pregnant women were included in the study. Most of the pregnant women were in the age group of 27 years. In our study, there was a significant decrease in intraoperative and postoperative blood loss in women receiving tranexamic acid. There was significant fall in post-operative haemoglobin in control group as compared to study group. Also, women who received tranexamic acid did not develop any significant complications. Conclusions: Tranexamic acid can be used safely as a prophylaxis to reduce blood loss during caesarean section.

Background: Congenital reproductive tract anomalies result from abnormal formation, fusion or resorption of the mullerian ducts during fetal life. Pregnancies with reproductive tract anomalies are known to have higher incidence of spontaneous abortions, fetal malpresentations, preterm labour, preterm premature rupture of membranes and increased cesarean section rate. The present study was conducted to describe the fetal and maternal outcomes among pregnant women with uncorrected reproductive tract anomalies in a tertiary care centre, Manipur, India.Methods: A hospital based cross sectional study was conducted among pregnant women with uncorrected reproductive tract anomalies in regional institute of medical sciences, Imphal, Manipur, India between September 2018 to August 2020.Results: A total of 62 pregnant women with uterine anomalies were included in the study. Bicornuate uterus was the most common uterine anomaly (45.2%) followed by arcuate uterus (19.3%). Cesarean section was conducted in 72.6% of the pregnant women and its major indication was fetal malpresentation (breech). Maternal complications were present in56.5% of the pregnancies and fetal complications in 27.4% of the newborns.Conclusions: The current study has shown a significant association between uterine anomalies and maternal and fetal complications including premature rupture of membranes, fetal malpresentation and increased caesarean section rate. Further studies involving bigger sample size will help in understanding the problem more and hence in the prevention of the complications in future.