Mental health literacy (MHL) was originally defined as knowledge and beliefs about mental disorders which aid their recognition, management, and prevention. More recently, this concept has evolved to a more positive perspective by adding the focus on knowledge and abilities necessary to benefit mental health. Higher levels of MHL have a positive influence on several domains. Therefore, MHL programs should be provided in different contexts across the lifespan. Mental health is now a major public health issue in modern societies, and higher levels of MHL can prevent and mitigate the impact of mental illness. For clinical practice, the authors recommend the use of the assertiveness, clear language, and positivity (ACP) model in MHL programs and strategies that encourage the implementation of these and other programs in different settings, as well as more research.