AbstrakRefluks laringofaring (RLF) adalah refluks cairan lambung melalui esofagus ke daerah laringofaring. Prevalensi RLF 15-20%, dan menjadi salah satu penyebab rinosinusitis kronik. Insidensi RLF pada penderita rinosinusitis kronik sebesar 37-72%. Prevalensi rinosinusitis kronik 16,3% pada dewasa dan berefek terhadap kualitas hidup. Omeprazol dan lansoprazol adalah proton pump inhibitor (PPI), digunakan sebagai terapi RLF, juga digunakan pada rinosinusitis kronik akibat RLF. Effectiveness Comparison between Omeprazole and Lansoprazole on the Improvement of Quality of Life in Patients with Chronic RhinosinusitisCaused by Laryngopharyngeal Reflux AbstractLaryngopharyngeal reflux (LPR) is the reflux of gastric acid through the esophagus that reaches laringopharyngeal area. The prevalence of LPR in the range 15-20%, and caused chronic rhinosinusitis (CRS). The incidence of LPR in patients with CRS has ranged between 37-72%. The prevalence of CRS 16,3% in adults and affecting quality of life. Omeprazole and lansoprazole are proton pump inhibitors (PPIs) for LPR's therapy and also a therapy for CRS with LPR as the etiology. This research method was randomized clinical trial with open trial observation, conducted in June to December 2009. Twenty subjects with consecutive sampling method, divided into two groups (with simple randomization), the first group received omeprazole and the other lansoprazole. The subjects conducted complete physical otolaryngology examination, sino-nasal outcome test 20, reflux symptom index and reflux finding score with fiber optic rhinolaryngoscopy. These data was obtained before therapy, after 2 weeks and two months therapy, analyzed with Wilcoxon's and Mann-Whitney's test. There was no effectivity difference between omperazole and lansoprazole in reducing the level of severity of LPR (p>0.05), but quality of life improvement was better in lansoprazole than omeprazole group (p<0.05). In conclusion, lansoprazole is more effective than omeprazole in improvement of quality of life in patients with chronic rhinosinusitis caused by LPR. [MKB. 2012;44(3):138-46].