The clinical range of Covid-19 is a respiratory route infection that varies from Asymptomatic to various clinical conditions such as respiratory failure to multiple organ dysfunction syndromes (MODS). Government administration officials are ramping up many efforts i.e prevention and containing the spread from escalating to the next level, raising the quarantine stations and increase in the laboratory capacity, strengthening surveillance, contact tracing using artificial intelligence (AI) via technology apps. India is Consequently facing many challenges to tackle the pandemic from shortage of medical supply to the devastation of the educational, transportation, job sectors, and healthcare sector, However, pharmaceutical companies taking center stage in the Covid-19 fight, Other pharmaceutical companies(low scale) in India are following suit during the Covid-19 pandemic and using their capabilities to lighten the burden of coronavirus, WHO recommends social distancing and country-wise lockdown are very essential to tackle the coronavirus, the GOI is scheming on how to get back to normalcy, with an actionable exit plan for the states to confront the coronavirus Bangladesh Journal of Medical Science Vol.19(0) 2020 p. S 88-S 92

Stereotypies are abnormal involuntary non-goal-directed movement patterns or vocalisations which repeat continuously in the same fashion over a period of time and on multiple occasions and are typically distractible. Stereotypies are common in both children and adults, but they are extensively reviewed only in children. There are very few studies, mainly in the form of case reports and case series, focusing on stereotypies occurring in adults as part of different neurological disorders. In adults, stereotypies can be both physiological and pathological. Common physiological stereotypies in adults are leg shaking, face touching, playing with pens or hair, nail biting, hand tapping, foot tapping, and body rocking. Pathological stereotypies in adults are associated with a variety of neuropsychiatric conditions like neurodegenerative disorders, viral encephalitis, autoimmune encephalitis, stroke, psychiatric illness, and drug use. In this review, we focus on the various causes of stereotypic movements in adults, and their pathophysiology, clinical manifestations, and treatment.

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Malaria is a severe human disease and a global health problem because of drug-resistant strains. Drugs reported to prevent the growth of Plasmodium parasites target various phases of the parasites' life cycle. Antimalarial drugs can inhibit key enzymes that are responsible for the cellular growth and development of parasites. Plasmodium falciparum dihydroorotate dehydrogenase is one such enzyme that is necessary for de novo pyrimidine biosynthesis. This review focuses on various medicinal chemistry approaches used for the discovery and identification of selective P. falciparum dihydroorotate dehydrogenase inhibitors as antimalarial agents. This comprehensive review discusses recent advances in the selective therapeutic activity of distinct chemical classes of compounds as P. falciparum dihydroorotate dehydrogenase inhibitors and antimalarial drugs.

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