Background Nanomaterials of curcumin with hyaluronic acid have gained a lot of attention for potential therapeutic applications of curcumin and hyaluronic acid with or without other additional drugs. Overall studies of curcumin and hyaluronic acid show that nanomaterials of curcumin with hyaluronic acid accelerate the efficacy of curcumin in the treatment of various disorders like arthritis, cancer, hepatic fibrosis, neural disorders, wound healing, and skin regeneration, it is largely due to the combined effect of hyaluronic acid and curcumin. However, due to limited clinical trials and experiments on humans and animals, there is a substantial gap in research for the safety and efficacy of nanomaterials of curcumin-hyaluronic acid in the treatment of curcumin and hyaluronic acid targeted diseases and disorders. Main body of the abstract In this current review, we have first described various reported synthetic nanomaterials of curcumin-hyaluronic acid, then in the next section, we have described various fields, disorders, and diseases where these are being applied and in the final section of this review, we discussed the research gap, and future research directions needed to propose the fabricated nanocurcumin-hyaluronic acid biomaterials. Short conclusion There are substantial gaps in research for the safety and efficacy of nanomaterials of curcumin with hyaluronic acid due to limited available data of clinical trials and experiments of nanocurcumin-hyaluronic acid biomaterials on humans and animals. So, it entirely requires serious and committed efforts through the well-organized system of practical and clinical trials which provide results, data, and detections that lead to the formulation of the best drug from curcumin with hyaluronic acid for the treatment of curcumin and hyaluronic acid targeted diseases and disorders.

It has been reported through various studies that turmeric of different geographical regions has variabilities regarding the number of phytochemicals, some have a better curcuminoid yield, some have better antimicrobial and antioxidant activities, and even turmeric of some regions does not show compatibility with modern applications due to having unfavorable quality. So, here in this study, we have tried to demonstrate the potential and efficacy of locally produced turmeric powder from district Kasur, Pakistan, through a comparative study with turmeric powder of international grade, analyzing their activity against pathogenic micro-organisms, presence of the number of phytochemicals, and presence of curcuminoid compounds like curcumin, extracted in four different solvents (ethanol, methanol, acetone and chloroform), and were verified by TLC and FTIR spectroscopy. This study justifies that the locally produced turmeric has better quality and potential as it gives a maximum curcuminoid yield of about 25% in Ethanol solvent and showed maximum zone of inhibition against E.coli about 14mm and 16mm against Staphylococcus aureus. While Antifungal activity was also observed high; as compared to the same amount of does of international grade turmeric extract. Further, electrospun nanofibers successfully generated from curcuminoid of Kasur Pakistan with PVA, present uniform, smooth nanofibers with an average diameter of 227. 49 nm. Finally, this study suggests that turmeric of Kasur has similar or more potential as compared to turmeric of international grade, and can be used/replaced in nanotechnology labs for various applications.

Medicinal plant Fagonia cretica L., is well known in traditional medicines for curing various complaints of human beings from ancient times and is locally known as Dhamasa. Previous many studies have reported the presence of many phytochemicals, antimicrobial, and antioxidant properties in the various parts of this plant. Therefore, here in this study, we have presented a comprehensive study on the presence of similar medicinal and chemical properties of Dhamsa found in Jamshoro District, Pakistan. For this study, extracts of the root, stem, leaf, and pod of the plant were prepared separately from three different solvents, water, ethanol, and methanol. Then the amount and presence of various phytochemicals, antimicrobial, antioxidant properties, and allelopathic effects were determined in all the extracts. The obtained results of this study confirm the presence of medicinal important phytochemicals in the plant extracts. The antimicrobial testing of this plant proved its highest activity against E. coli (16 ±1.4mm), Salmonella typhi (18±0.7mm), and Pseudomonas aeruginosa (15±1.4mm) in methanol, water, and ethanol extracts respectively. The presence of antioxidant activities was also observed in the ethanolic extract of the leaf at about 0.98 mg/ml. While this plant showed allelopathic effects on the growth of radish and spinach plants. So, we have concluded this study that Fagonia cretica L., collected from Jamshoro has the same or more important properties compared to the same plant from other regions, which proves the similar significant value of the Fagonia cretica plant of Jamshoro in various fields of medicinal sciences.