Increasing numbers of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) are occurring in several countries and continents. Information regarding the impact of cardiovascular complication on fatal outcome is scarce.OBJECTIVE To evaluate the association of underlying cardiovascular disease (CVD) and myocardial injury with fatal outcomes in patients with COVID-19.

Starting around December 2019, an epidemic of pneumonia, which was named COVID-19 by the World Health Organization, broke out in Wuhan, China, and is spreading throughout the world. A new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group of the International Committee on Taxonomy of Viruses was soon found to be the cause. At present, the sensitivity of clinical nucleic acid detection is limited, and it is still unclear whether it is related to genetic variation. In this

Quantifying and attributing the phenological changes in snow cover are essential for meteorological, hydrological, ecological, and societal implications. However, snow cover phenology changes have not been well documented. Evidence from multiple satellite and reanalysis data from 2001 to 2014 points out that the snow end date (De) advanced by 5.11 (±2.20) days in northern high latitudes (52–75°N) and was delayed by 3.28 (±2.59) days in northern mid-latitudes (32–52°N) at the 90% confidence level. Dominated by changes in De, snow duration days (Dd) was shorter in duration by 5.57 (±2.55) days in high latitudes and longer by 9.74 (±2.58) days in mid-latitudes. Changes in De during the spring season were consistent with the spatiotemporal pattern of land surface albedo change. Decreased land surface temperature combined with increased precipitation in mid-latitudes and significantly increased land surface temperature in high latitudes, impacted by recent Pacific surface cooling, Arctic amplification and strengthening westerlies, result in contrasting changes in the Northern Hemisphere snow cover phenology. Changes in the snow cover phenology led to contrasting anomalies of snow radiative forcing, which is dominated by De and accounts for 51% of the total shortwave flux anomalies at the top of the atmosphere.

For several decades, long-term time series data sets of multiple global land surface albedo products have been generated from satellite observations. These data sets have been used as one of the key variables in climate change studies. This study aims to assess the surface albedo climatology and to analyze long-term albedo changes, from nine satellite-based data sets for the period 1981-2010, on a global basis. Results show that climatological surface albedo data sets derived from satellite observations can be used to validate, calibrate, and further improve surface albedo simulations and parameterizations in current climate models. However, the albedo products derived from the International Satellite Cloud Climatology Project and the Global Energy and Water Exchanges Project have large seasonal biases. At latitudes higher than 50°, the maximal difference in winter zonal albedo ranges from 0.1 to 0.4 among the nine satellite data sets. Satellite-based albedo data sets agree relatively well during the summer at high latitudes, with a standard deviation of 0.04 for the 70°-80°z one in both hemispheres. The fine-resolution (0.05°) data sets agree well with each other for all the land cover types in middle to low latitudes; however, large spread was identified for their albedos at middle to high latitudes over land covers with mixed snow and sparse vegetation. By analyzing the time series of satellite-based albedo products over the past three decades, albedo of the Northern Hemisphere was found to be decreasing in July, likely due to the shrinking snow cover. Meanwhile, albedo in January was found to be increasing, likely because of the expansion of snow cover in northern winter. However, to improve the albedo estimation at high latitudes, and ultimately the climate models used for long-term climate change studies, a still better understanding of differences between satellite-based albedo data sets is required.

SUMMARY Emerging data implicate microRNAs (miRNAs) in the regulation of synaptic structure and function, but we know little about their role in the regulation of neurotransmission in presynaptic neurons. Here we demonstrate that the miR-310-313 cluster is required for normal synaptic transmission at the Drosophila larval neuromuscular junction. Loss of miR-310-313 cluster leads to a significant enhancement of neurotransmitter release, which can be rescued with temporally restricted expression of mir-310-313 in larval presynaptic neurons. Kinesin family member, Khc-73 is a functional target for miR-310-313 as its expression is increased in mir-310-313 mutants and reducing it restores normal synaptic function. Cluster mutants show an increase in the active zone protein Bruchpilot accompanied by an increase in electron dense T-bars. Finally, we show that repression of Khc-73 by miR-310-313 cluster influences the establishment of normal synaptic homeostasis. Our findings establish a role for miRNAs in the regulation of neurotransmitter release.