In order to simplify the complexity and reduce the cost of the microphone array, this paper proposes a dual-microphone based sound localization and speech enhancement algorithm. Based on the time delay estimation of the signal received by the dual microphones, this paper combines energy difference estimation and controllable beam response power to realize the 3D coordinate calculation of the acoustic source and dual-microphone sound localization. Based on the azimuth angle of the acoustic source and the analysis of the independent quantity of the speech signal, the separation of the speaker signal of the acoustic source is realized. On this basis, post-wiener filtering is used to amplify and suppress the voice signal of the speaker, which can help to achieve speech enhancement. Experimental results show that the dual-microphone sound localization algorithm proposed in this paper can accurately identify the sound location, and the speech enhancement algorithm is more robust and adaptable than the original algorithm.