Aryl hydrazides with a ketone or aldehyde containing side chains linked to the meta-position of the aromatic ring undergo acid-promoted intramolecular Fischer indole synthesis to generate 3,4-fused tricyclic indoles. The preparative utility of this conceptually new synthetic approach, which does not require prefunctionalization of the indole ring, was demonstrated by its application to a concise total synthesis of (-)-aurantioclavine.

A highly enantioselective desymmetrization of prochiral cyclopentene-1,3-dione via [3 + 2] cycloaddition of azomethine ylide using a silver(I)-ferrophox complex has been demonstrated. The method has been utilized in the synthesis of highly functionalized enantioenriched 5,5-fused bicyclic pyrrolidine derivatives under mild reaction conditions.

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The 1,3-dipolar cycloaddition reaction of nitrone is one of the most important methods for the synthesis of different sizes of heterocycles which have enormous applications in natural products, biologically active molecules and pharmaceuticals.

First asymmetric synthesis of the naturally occurring epoxy noneolide stagonolide-D has been reported in this article. Ring-closing metathesis (RCM) by Grubbs second generation catalyst, Sharpless asymmetric epoxidation (SAE), and cis-selective Horner–Wadsworth–Emmons (HWE) olefination by Ando method are the key reactions successfully employed to achieve the target molecule in a divergent approach. Structurally related small ring macrolide stagonolide-G has also been synthesized by employing RCM and a metal–enzyme combined dynamic kinetic resolution (DKR) strategy starting from (S)-ethyl lactate as a chiral pool.