Introduction:Restless legs syndrome (RLS) is a common neurological disorder affecting 10% of the population. Most antidepressants exacerbate symptoms; however, correlational studies have noted symptom improvement with bupropion. The purpose of the current study was to examine whether, in a controlled study, bupropion would improve the symptoms of RLS, or at least not exacerbate them.Methods: This was a double-blinded, randomized controlled trial. Twenty-nine participants with moderate to severe RLS received 150 mg sustained-release bupropion once daily, and 31 control participants received a placebo. Participants were followed for 6 weeks and completed standardized tools, including the International Restless Legs Syndrome Study Group (IRLSSG) severity scale.Results: The primary outcome was change from baseline in IRLSSG severity score; lower scores were associated with improved symptoms. At 3 weeks, IRLSSG scores were 10.8 points lower in the bupropion group and 6.0 points lower in the placebo group (P ‫؍‬ .016). At 6 weeks, IRLSSG scores were10.4 points lower in the bupropion group and 7.6 points lower in the placebo group (P ‫؍‬ .108). Bupropion was more effective than placebo in the treatment of RLS at 3 weeks; however, this difference was not statistically significant at 6 weeks.Conclusions: The data from our study suggest that bupropion does not exacerbate the symptoms of RLS and may be a reasonable choice if an antidepressant is needed in individuals with RLS. Larger studies that include titration of bupropion should be considered to determine if bupropion is appropriate for primary treatment of RLS, particularly considering the lower cost and favorable side effect profile compared with currently recommended first-line dopamine agonists. (J Am Board Fam Med 2011;24: 422-428.)

Purpose Many corporates in India are constantly working to adapt new sustainable working practices that can reduce average space usage in the Indian workspace. This study aims to analyze the strategic shifts in terms of new approaches to work (NAW) adopted by information technology (IT) companies, influenced by sustainable practices that have a positive impact on the reduction in usage of brick and motor workspace and carbon footprint. Design/methodology/approach The research is descriptive in nature. A questionnaire survey was sent to certified ISO 41001 Indian IT companies to collect data through SurveyMonkey. Stratified sampling was used to collect a sample of 583 respondents, which was also verified using G* software. The data collected was analyzed using descriptive statistics and partial least square-structured equation modeling (PLS-SEM) to analyze the mediating effect of sustainability on NAW and reduction in usage of workspace. Findings The structural model results obtained through the bootstrapping technique showed that sustainability has become essential to survive in a competitive business environment while developing NAW that can reduce workspace usage. The findings of this study support the partial mediation effect (38%) of sustainability on NAW and workspace usage patterns in the Indian IT workspace. Originality/value This research adds value to the limited literature on the effect of NAW in the Indian IT sector and provides empirical evidence of the impact of technology-enabled NAW based on sustainable practices that can help reduce the demand for workspace.

PurposeProperty management in commercial real estate (CRE) is an important operational function that needs to be managed because it brings large cost implications to the organization. As India aspires to become a developed real estate market, analysis of the growing importance of automating property services and technology acceptance by stakeholders are two key concerns that need to be explicitly addressed. This study aims to examine the extent of property technology (PropTech) adoption in India and propose a technology-enabled stakeholder management model in Indian CRE.Design/methodology/approachThe research is qualitative in nature and follows the grounded theory approach. Research data were collected by conducting a series of semi-structured interviews with 18 property management professionals from different prominent Indian companies using PropTech.FindingsThe findings suggested the nine most typical automated property management functions in Indian CRE. The result of this research is the automated property services model for stakeholder management in CRE. The model demonstrates the value of implementing technology in property services in India.Practical implicationsThe study provides useful insights into how artificial intelligence (AI) in property management can be applied to address property-related challenges, various stakeholder needs and improve property performance in accordance with energy efficiency policies.Originality/valueThis paper attempts to add to the limited body of literature on technology in the property management domain. The model demonstrates how automated property services meet the needs of different stakeholders in CRE and provides remote working procedures within the COVID-19 pandemic context.

PurposeMany corporates in India are constantly adapting real estate benchmarks to reduce the workspace maintenance cost. However, anecdotally benchmarking the experience of clients while designing the workspace maintenance policies is not adequately taken into consideration in India. The focus of this study is on benchmarking workspace usage based on client usability.Design/methodology/approachThe research is descriptive in nature. A structured questionnaire was sent to Information Technology (IT) companies in India to collect data through SurveyMonkey. Stratified sampling was used to collect a sample of 697 respondents which was also verified using G* software. The data collected was analysed using descriptive statistics and partial least square–structured equation modeling (PLS-SEM) to investigate the mediating effect of benchmarking the workspace usage on portfolio optimization and client satisfaction.FindingsThe structural model results obtained through the bootstrapping technique show that benchmarking workspace usage for real estate management positively impacts client satisfaction in the Indian IT workspace. The findings of this study support the full mediation effect (97%) and indicate that benchmarking practices are necessary for developing strategies for optimal portfolio asset utilization and are essential to survive in the current competitive business environment.Research limitations/implicationsThe findings of this study were influenced by the feedback from the top 100 IT clients in India. The research findings vary according to the cost-benefit analysis of adopting benchmarking measures in small and medium-sized IT companies which still benchmark the workspace usage based on cost-saving measures. Also, very sparse research has been conducted in the workspace management domain of IT firms, so the results of this study can further be used as a reference to explore this area.Practical implicationsThe study provides useful insights into how benchmarking in the workspace management domain of the CRE industry can be applied to address portfolio-related challenges, divergent client needs and improve workspace usability following energy-efficient policies. Practitioners can use this study as a guide to develop more effective workspace management policies.Social implicationsThis study may guide other firms to benchmark their current workspace usage and evaluate the impact of their workspace management policies based on the theoretical framework of value-added balanced benchmarking criteria.Originality/valueThis research adds value to the limited literature available on the impact of technology-enabled portfolio optimization techniques through benchmarking which can reduce workspace usage and enhance the usability of the workspace.

PurposeHoly cities in India are seeing tremendous gentrification. This study aims to investigate the effect of the changing lifestyle of people towards spirituality and the changing lifestyle's impact on consumer buying behavior on properties in Indian holy cities which has not been studied anecdotally.Design/methodology/approachThe research is exploratory in nature. A questionnaire has been sent to collect primary data through SurveyMonkey. Simple random sampling was used to collect a sample of 450 respondents which was also verified using G* software. The data were analyzed using descriptive statistics and partial least square–structured equation modeling (PLS-SEM).FindingsFindings obtained through the structural model using bootstrapping technique suggest that intrinsic and extrinsic factors are attracting tourists leading to an increase in the demand for real estate in holy cities.Research limitations/implicationsThe research findings may vary as per the cultural differences and belief in spirituality, which is subject to perceptual biases in different holy cities.Practical implicationsThe traditional determinants of property buying behavior are considered inadequate to attract real estate investments. The inclusion of these behavioral aspects – intrinsic and extrinsic factors may improve the investment inflows in India.Social implicationsSpirituality connects to the concept of behavioral real estate, where the decision to buy property is largely affected by the emotional attachment of people.Originality/valueThis research adds value to fill the gap by finding out the latent determinant – emotional reasons impacting transnational gentrification in India.