In this paper, we studied a two-parameter transmuted model of Log-logistic distribution (LLD) using the quadratic rank transmutation map technique studied by Shaw and Buckley1 as a new survival model in medical sciences and other applied fields. Statistical properties of Transmuted LLD (TLLD) are discussed comprehensively. Robust measures of skewness and kurtosis of the proposed model have also been discussed along with graphical overview. The estimation of the model parameters is performed by Maximum Likelihood (ML) method followed by a Monte Carlo (MC) simulation procedure to investigate the performance of the ML estimators and the asymptotic confidence intervals of the parameters. Applications of the proposed model to real-life data are also presented.

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The polymorphism associated with hepatocyte-specific promoter region (- 10T/C) is likely to be associated with the pathogenesis of COPD. It is quite possible that the change of the base in the hepatocyte-specific promoter of the SERPINA1 gene can modulate its strength, thereby driving the reduced expression of α1AT.

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