Primary mucinous carcinoma of the skin is a rare malignant tumour of sweat gland origin. Diagnostic concerns include its deceptively benign appearance in some cases and the difficulty in differentiating it from secondary mucinous carcinoma of skin metastasising from a primary source elsewhere. A case of a 75-year-old man is reported who presented with a slowly growing painless mass near the lateral canthus of the right eye for about 2 years. Clinically, a diagnosis of basal cell carcinoma was made whereas histopathology revealed mucinous carcinoma of the skin. The primary source of the tumour could not be found on detailed physical examination and laboratory investigations. Immunohistochemistry, performed later, was consistent with primary cutaneous mucinous carcinoma.

Objective:To study and detect immunohistochemical expression of Estrogen Receptors, Progestrone Receptors and HER-2/neu Receptors in Endometrial Carcinoma (EC) and to find their associations with histological types, grades and stages of the tumor.Methods:A cross sectional study of one year duration from January 2016 to January 2017 was conducted at Histopathology department of Army Medical College, Rawalpindi. A non-probability purposive sampling technique was used to include 56 cases of EC. The specimens were tested for ER, PR and HER-2/neu expression using immunohistochemical analysis. Data was analyzed in SPSS and the significance of association of expression of the receptors with histological types, grades and stages of the tumor was assessed.Results:Significant association of Her-2/neu overexpression with histological types and grades of EC was seen, whereas the association of ER and PR expression with histological types, grades and stage of EC was statistically insignificant.Conclusion:It is suggested that EC showing over expression of HER2/neu with immunohistochemistry may be treated with anti HER-2/neu treatment with better chances of survival and decreased post-treatment morbidity.

By using microscopy and immunohistochemical techniques, GISTs can be diagnosed accurately and treated efficiently. Risk stratification and histological subtyping have emerged as efficient tools to predict malignant behavior.

To our knowledge, ours is the first case of intraprostatic fat described in routine diagnostic material. The existence of intraprostatic fat suggests that invasion of fat by prostatic adenocarcinoma in needle biopsies may not always represent extraprostatic extension of tumour.However, review of the literature and our personal experience suggests that the presence of intraprostatic fat is exceedingly rare and, for practical purposes, prostatic cancer invading fat should still be considered as most in keeping with extraprostatic extension and staged as pT3a.NOTE: A recent paper published subsequent to the acceptance of this manuscript has reported intraprostatic fat in 3.98% of 427 radical prostatectomy specimens. 5Sir: Primary angiosarcoma of the breast is a rare entity, although secondary angiosarcomas arising subsequent to radiotherapy, trauma and axillary clearance are relatively common. The frequency of this rare tumour is 0.04% of primary breast tumours and approximately 8% of breast sarcomas. 1 Phyllodes tumour comprises 1% of breast malignancies 2 and is not a rare neoplasm.Sarcomas arising in malignant phyllodes tumours include rhabdomyosarcoma, chondrosarcoma, osteosarcoma and liposarcoma. 3,4 Angiosarcoma arising in phyllodes tumour has not been documented so far, to the best of our knowledge, despite a rigorous search of medical literature. A case of angiosarcoma arising in a recurrent phyllodes tumour is presented.A 30-year-old lady presented with two lumps in the right breast a year previously that were excised and each was reported as fibroadenoma on histopathological examination. After 3 months, a third lump developed, which was excised and diagnosed as a benign phyllodes tumour. After another 3 months a small lump again appeared at the 12 o'clock position, which increased in size over 6 months to a size of 80 · 70 mm occupying the upper medial and lateral quadrants and subareolar region of the breast. The lump was painful but there was no nipple discharge or retraction. The patient had not received any radiotherapy in the past. On core needle biopsy, a vascular neoplasm was diagnosed and a suspicion of malignancy was raised. Immunohistochemistry for CD31 and CD34 was positive (Figures 1 and 2). Excision biopsy was suggested. On gross examination, the specimen consisted of a skin-covered fibrofatty piece of tissue measuring 90 · 60 · 50 mm. On sectioning there was a greyish white, well-circumscribed nodule measuring 55 · 45 · 30 mm, with a 15 · 15 mm, dark brown, ill-defined area merging with it ( Figure 3). The nodule was 15 mm away from the closest deep resection margin. Figure 1. Trucut biopsy specimen of the breast. Endothelial cells lining the vessels are immunoreactive with CD31.