Crystalline particles of am icroporous, robust, and chiral metal-organic framework (MOF) were synthesized andt heir enantiomer excess( ee)w as visualizedf or each microparticle by CD imaging. Labtb,athermally and chemically robust MOF,w as employedi nt his study because it showsachirals pace group. Although Labtb has been obtained as ar acemic conglomerate, enantioselective synthesis of Labtb was achieved via ac hiral precursor complex consisting of lanthanum and homochiral phenylalanine.M ethyl orange( MO) was introduced into the micropores of chiral Labtb,w hich showed as trong induced CD signal for the absorption band of MO chromophores. High ee of the chiral Labtb was revealed by microscopic CD observationa tt he particle-level.T his result provides a facile way to obtain ar obustM OF that has chiral nanospace.Molecular recognition of chirality is essential in biochemistry and pharmaceuticals. It is of paramount importance to develop chiral-recognizable molecular systemsw hich show sophisticated multipointi nteractions toward the chiral molecules. In this regard, chiralm etal-organic frameworks (CMOFs) has been attracting great interest because they contain regularm icropore structures, which are highlyd esignable. CMOFscan be classifiedinto two categories. One group consists of homochiral organic ligandso rl inkers complexed to metal ions. [3][4][5][6][7][8][9][10][11][12][13] Kim and co-workerss ucceeded in constructing ac hiral MOF by using enantiopure ligandsa nd reported the enantioselective guest adsorption and catalytic performance. [9] Lin and co-workersr eported ab ridging ligand containing axial chirality to synthesize porousc hiral MOF that could be used as an enantioselective catalyst. [17,18] Fujita and co-workers utilized ah omochiralo rganic ligand. [3] Although these approaches promise homochirality of the obtained CMOFs, they require enantiopure ligands that usually requireanumber of synthetic steps.M oreover,t he chiral centers of these CMOFs are localized at the organic units,w hich are often unstable at elevated temperatures.The other group of CMOFsi sc omprised of achiral bridging ligands,y et they revealc hirality in the framework structure. To inducec hiral molecular arrangementi nt he coordination networks, chiral molecules are employeda ss tructure-directing reagents. [14][15][16][19][20][21][22][23] Su, Wang and co-workersr eported a Cd(bpdc) 1.5 framework consisting of octuple helices and chiral pores, and inductiono ft he chirality was achieved by the addition of l-leucine in the reactionm ixture. [14,6] Morris and coworkersr eported an enantiopure [Ni 3 (Hbtc) 4 ]( H 3 btc = trimesic acid) framework synthesized by using ac hiral ionic liquid containinga spartate. [15] Zaworotko and co-workers reported that MOF-5 could take ac hiral arrangemento ft he aryl rings upon the addition of homochiral proline. [16] Yaghi and co-workers pickedu pas ingle crystal of MOF-520 from its racemic conglomerate and determined the structure of the guest by XRD analysis. [2] These approaches use simp...

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