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Introduction: Chronic leg ulcers pose a formidable challenge to the surgeon necessitating various treatment modalities. Due to recurrence in wounds with conventional therapy, newer modalities of treatment with PRP showed promising results in various branches of medicine like plastic and reconstructive surgery, orthopedics, and dermatology, cardiovascular and thoracic surgery. Study aimed to record the effect of platelet rich plasma in the treatment of chronic ulcers particularly venous and diabetic leg ulcers. Material and methods:A prospective study of 10 cases of chronic leg ulcers. Chronic leg diabetic ulcers, venous foot ulcers of more than 3 months duration both males and females with normal platelet count and activity are selected. Age group between 18ys and 60 yrs with ulcers between size varying 2x2cm 2 to 10 x10 cm2 were included.Results: Wounds were measured on day O along their greater dimensions and were recorded, which ranged from 3x3 cm2 to 10x8. At the end of 2nd week, ulcer size had reduced by an average of 21.87% (range 0%-60%) in 10 wounds. Healing of the ulcers with full re-epithelialization was seen in 4 cases (40%). Of the remaining ulcers, 6 (60%) were taken up for skin grafting once the ulcer has granulated well. In these cases of skin grafting, 5 ulcers have healed completely with 1 case of graft failure Time taken for the wounds to heal completely by re-epithelization ranged from 6 weeks (1 venous ulcer) to 16 weeks (1 diabetic foot ulcer). Of the ulcers (n=6, 60%) which underwent skin grafting, 5 (83.33%),healed completely, with 1 case of graft fail. Conclusion:The use of platelet-rich plasma can be an option when treating recalcitrant wounds of differing etiologies.How to cite this article: M Swatantra Bharathi, Tarun. Role of platelet rich plasma [PRP] in the treatment of chronic wounds.