Vaso-vagal reflex is a significant and common complication in paediatric patients with cardiac catheterization. Vaso-vagal reflex includes several symptoms, such as tachycardia, pressure, light headedness, nausea, or cyanosis that are severe threats to cause death. To understand the vaso-vagal reflex among paediatric patients with cardiac catheterization, we conducted integrative literature to review content about nursing with the reflex. We reviewed, analysed, and synthesized published research and grey literature between 2006 and 2016. Results were found that there were 9 papers related to vaso-vagal reflex among paediatric patients with cardiac catheterization. Overall, content about vaso-vagal reflex in paediatric patients with cardiac catheterization included three aspects. First, it was assessment of disorders and complications. Because paediatric patients with cardiac catheterization experienced changes in emotional and behavioural signs, nurses should concern and focus on these changes. Second, it was nursing to prevent irregularities and complications. Nurses need to care of the paediatric patients to reduce the pain, reducing anxiety and reducing fear. Lastly, it focuses on nursing after disorders and complications. Nurses care of the patients to get drugs or fluids to cause nausea and vomiting. Moreover, they nurse the patients with Trendelenburg position to prevent vaso-vagal reflex. Although there was little paper about the vaso-vagal reflex among paediatric patients with cardiac catheterization, it was the fundamental information to study and develop nursing practice guidelines based on the evidence vaso-vagal reflex in paediatric patients with cardiac catheterization for the future research.