The present authors report the case of an adult male with no medical history, who developed prolonged fever of unknown cause, progression of anemia and lung fibrosis. A hematological disease was suspected and further investigations were done. The bone marrow aspirate raised the suspicion of Gaucher’s disease. The positive diagnosis was Gaucher’s disease with lung involvement (pulmonary fibrosis and pulmonary hypertension), and cardiac involvement (restrictive cardiomyopathy). Clinical evolution was unfavorable, and the patient died of cardiorespiratory failure. In conclusion, the present case report illustrates a late diagnosis of Gaucher’s disease with lung and cardiac involvement resulting in death in a short period

Introduction. The infection with hepatitis C (HCV) is a major cause of chronic liver diseases, with approximately 71,000.000 chronically infected persons worldwide. Material and methods. This study includes the results of the evaluation of the quality of life of patients with chronic hepatic diseases, on a group of 122 patients divided into two lots. The study period was January 2020 - december 2022. Our aim was to study the impact of the antiviral therapy on the patients quality of life before and after the interferon free antiviral therapy, as well as to study the quality of life of the patients with chronic viral hepatitis C who did not receive interferon free antiviral therapy because they did not meet the eligibility criteria, but accepted to participate in the study. Results. Following the analysis and the interpretation of the questionnaire used, we found that the patients who did not receive the treatment presented more frequently a psychosocial unbalance (social activities), psychoemotional and loss of interest for the sexual activity. In the case of patients treated with interferon free regimens we found an improvement of the quality of the whole duration of the therapy, this being correlated, especially, with drug interaction that were limited or easily manageable and had minimal adverse effects, increasing psychoemotional, balance, and the sexual activity was not influenced. Conclusions. The results of our study indicate that the patients who were treated with the antiviral interferon free therapy become aware the fact that the problems related to the chronic hepatic disease are solvable, which influences the quality of life in a positive way.

Background: Pulmonary embolism (PE) represents the third most frequent vascular disease following acute myocardial ischemic disease and stroke. It is a common and potentially lethal disease. Aim: We observed etiological spectrum, clinical aspects and diagnostic tests for patients with PE. Material and methods: Retrospective observational study that included 53 patients diagnosed with PE between 01.01.2009- 31.12.2013. We followed epidemiological aspects, risk factors, clinical manifestations and methods for positive diagnosis. Results: 53 patients which represents 0.66% from the patients admitted in our department (n=8,011), were diagnosed with PE. The main risk factor for PE was malignancy (n=16). Twenty patients with PE presented deep venous thrombosis (DVT) and 12 patients arterial thrombosis (AT). Main clinical syndromes of patients with PE were pulmonary infarction (n=32), isolated dyspnea (n=11) and circulatory collapse (n=10). A lot of paraclinical investigation sustained positive diagnosis,mainly by high performance techniques. Four cases were diagnosed postmortem. Conclusions: Clinical diagnosis of PE has a low accuracy. Clinical evaluation, even unspecific has a considerable value in the selection of patients who needed further paraclinical diagnostic procedures.