Background: ITAM-harboring DAP12 contributes to functional osteoclast formation. Results: Siglec-15 is NFAT2-inducible and functions with DAP12 to promote functional osteoclast development. Conclusion: Siglec-15 links RANKL-RANK-NFAT2 signaling with ITAM-mediated signaling during osteoclast development. Significance: Our results provide new insights into how DAP12 transduces extracellular signals into osteoclasts.
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