Our GWAS identified 22 independent loci showing suggestive association signals with degenerative bony changes of the TMJ. These loci provide good candidates for future follow-up studies.

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The patient, a male aged 18 years and 7 months, complained of not being able to bite with his anterior teeth. He was diagnosed as having open bite with osteoarthritis of the temporomandibular joint TMJ-OA. He did not have closed lock in the TMJ, but had pressure pain. This symptom was improved through use of a stabilization splint, and a stable mandibular position was obtained. Treatment involved use of edgewise orthodontic appliances and extract of the first premolars upper and lower. It is necessary to consider the progressive mandibular retrusion from the progression of OA in orthodontic treatment of open bite with TMJ-OA. In this case, good anterior and molar relation, and temporomandibular function were achieved through use of a treatment plan set after checking the mandibular position.

The purpose of this study was to investigate the relationship between the TMJ-ID and craniofacial morphology. Eighty-five female patients with bilateral disc displacement were selected as subjects from 163 orthodontic patients with signs and symptoms of TMD who underwent MRI examination before treatment. The subjects were divided into three groups: patients with bilateral disc displacement DD , patients with unilateral TMJ-OA UOA , and patients with bilateral TMJ-OA BOA . The patients without disc displacement and TMJ-OA N were control subjects. Craniofacial morphology was analyzed on postero-anterior cephalograms. The Tukey-Kramer method was used for statistical comparisons among the four groups.The following measurement items showed significant differences between the N group and the other three groups Y-Me DD: p 0.05, UOA and BOA: p 0.01 , Mo-diff BOA: p 0.05 , Hlf DD, UOA and BOA: p 0.01 , Ocl UOA: p 0.05 . In the UOA, all the patients except one exhibited lateral shift of the Me point that progressed to the intraarticular pathologic side. In the DD and BOA groups, differing from the UOA, the rule did not apply in the direction of the mandibular shift.These findings show that bilateral TMJ-ID is related to lateral shift of the mandible. Furthermore, craniofacial asymmetry in bilateral TMJ-ID was not a characteristic clinical sign of the UOA, a fact that was clear when looking at the DD and the BOA groups. Therefore, it was suggested that there was relativity between the bilateral TMJ-ID and craniofacial asymmetry.