Abstract. A method for the complex treatment of patients with chronic gingivitis is applied, including the application of trypsin in 1% solution of sodium bicarbonate, topical medication Qudesan and sonication, using a curette scaler with the toe. The clinical efficiency of the proposed method in the dynamics of treatment 55 patients with chronic gingivitis is counted. The use of complex therapy in accordance with the described method allows us to achieve a total destruction of the microbial biofilm in 7-8 days, which significantly improves the health and condition of the periodontal tissues, as well as the general condition of the patients after 2-3 weeks.