This study assesses the severity of psychopathological symptoms among the groups in strict quarantine and the population without self-isolation in the context of the COVID-19 pandemic. From April 18 to June 15, 2020, an online survey was conducted using the symptomatic questionnaire (SCL-90-R) adapted by N. V. Tarabrina in a sample of 837 residents of Russia, Kazakhstan, Belarus and other states. 426 respondents followed the strict regime of self-isolation at home; 302 were on self-isolation, but could go to work; 109 were not subjected to self-isolation. As a result, the indices of anxiety, depression, somatization, obsessive-compulsive disorders, hostility, psychoticism, and the general index of severity were significantly higher in those in strict quarantine than in those without self-isolation (p<0.05). Therefore, there is a need to organize accessible psychiatric and psychological support for the population under conditions of quarantine.