Aloevera can protect and restore the function of damaged pancreatic beta cells. The content of aloe vera can work like insulin, and lower blood glucose even though all beta cells have degenerated. The aim of the study was to find out the effect of aloe vera extract on the regulation of blood glucose levels in rats induced by streptozotocin. The study was true experimental randomized pre-post test control group design. The sampling technique used simple random sampling consisting of 20 wistar strain rats divided into 4 groups, namely the placebo control group, treatment group with a dose of 250 mg/dl, a dose of 350 mg/dl, and a dose of 1000 mg/dl. Rats were given STZ injection on day 8 after acclimatization. The independent variable was aloe vera extract. The dependent variable was blood glucose levels. The intervention of giving aloe vera extract was given for 9 days. Data were analyzed by Paired t Test and ANOVA. The results showed that there was an effect of aloe vera extract at a dose of 350 mg/kgBW on blood glucose levels with a paired t test of 0.022. The ANOVA results showed that aloe vera extract at a dose of 350 mg/kgBW had the highest effectiveness with a p value of 0.05. The chromium, alprogen, and flavonoid in aloe vera will improve the beta function of the pancreas in producing the hormone insulin. Damage to the islets of Langerhans cells in the pancreas will be inhibited and restore the sensitivity of the insulin receptor cells.methods that are attractive to high school students and carried out consistently.

Perubahan gaya hidup terutama dikota besar,menyebabkanpeningkatan prevalensi penyakit degeneratif seperti Diabetes Mellitus.Tungkai bawah terutama kakisering bermasalah akibatnya perfusi jaringan bagian distal dari tungkai menjadi kurang baik dan timbul ulkus yang dapat berkembang menjadi nekrosis/gangren.Tujuan penelitian untuk menjelaskanpengaruh senam kaki DM terhadap perubahan nadi dorsalis pedis. Penelitian menggunakan Quasy-experimentalpre-post test design. Populasi penelitian ini berjumlah 30 responden yang terbagi dalam kelompok perlakuan dan kontrol. Analisis data menggunakan Wilcoxon sign ranked test untuk 2 sampel berpasangan, dan mann whitney test untuk 2 sampel bebas. Hasil uji pre test Mann-Whitneytestnilai p = 0.417sedangkan uji post test Mann-Whitneynilai p = 0.003. Hasil uji pre-post test kelompok perlakuan menggunakan Wilcoxon Signed ranked nilai p = 0.008sedangkan uji pre-post test kelompok kontrol menggunakan Wilcoxon Signed ranked nilai p = 0.564. Hasil penelitian ini menunjukkanada pengaruh senam kaki DM terhadap perubahan nadi dorsalis pedis. Senam kaki DM yang dilaksanakan minimal 3 kali seminggu dalam jangka waktu 3 minggu terbukti memberikan pengaruh pada vaskularisasi perifer dan kestabilan glukosa darah. Senam meningkatkan Nitric Oxode Syntesis dan vasodilatasi arteri.Saran penelitian adalahmengembangkan model pencegahan impairmentulkus diabetikum berdasarkan teori keperawatan lainnya.

Pendahuluan: Diabetes Mellitus merupakan penyakit metabolik kronis. Diabetic foot ulcers merupakan komplikasi yang sering terjadi akibat kadar glukosa yang tidak terkontrol.  Tujuan penelitian menjelaskan pengaruh senam kaki terhadap status vaskularisasi perifer dan glukosa darah. Metode: Penelitian menggunakan quasy experimental pre-post test control group design. Populasi berjumlah 30 responden yang terbagi dalam kelompok perlakuan dan kontrol. Teknik sampling menggunakan purposive sampling. Kriteria inklusi meliputi klien DM berusia >45 tahun, DM tipe II, dan glukosa darah acak < 300 mg/dl. Kriteria eksklusi meliputi klien ulkus diabetikum, GDA >300 mg/dl, gout artritis. Intervensi senam kaki diberikan 3 kali seminggu selama 4 minggu. Pengukuran variabel capilarry refill time menggunakan observasi penekanan ujung jari. Pengukuran variabel glukosa menggunakan glukosa stick-test. Analisis data menggunakan Wilcoxon & mann whitney test digunakan mengukur variabel capillary refill time. Independent & paired t-test digunakan mengukur variabel glukosa. Hasil: Uji variabel CRT menggunakan Mann-Whitney test menunjukkan nilai p = 0.022 yang berarti ada pengaruh senan kaki tehadap capillary refill time. Hasil uji variabel Glukosa darah menggunakan paired t test menunjukkan p=0.004, dan independent t test menunjukkan p=0.012 yang berarti ada pengaruh senam kaki terhadap kadar glukosa darah. Diskusi: Senam kaki terbukti meningkatkan Nitric Oxode Syntesis, vasodilatasi arteri, terjadi pembakaran gula darah yang mengakibatkan turunnya gula darah, afinitas oksigen hemoglobin, dan viskositas darah. Sebaliknya, terjadi peningkatan sirkulasi darah, saturasi oksigen, perfusi jaringan, dan sistem imunitas sehingga dapat mencegah ulkus kaki diabetik. Dalam upaya preventif, sebaiknya dinas kesehatan khususnya puskesmas untuk menyediakan media promosi kesehatan melalui penyediakan booklet senam kaki kaki. Introduce: Diabetes Mellitus was a chronic metabolic disease. Diabetic foot ulcers were a complication that often results from uncontrolled glucose levels. This study was to explain the effect of foot exercises on the status of peripheral vascularization and blood glucose. Methods: The study was quasy experimental design. The population were 30 respondents divided into treatment and control group. The sampling technique uses purposive sampling. Inclusion criteria included client DM aged >45 years, DM type II, and random blood glucose <300 mg/dl. Exclusion criteria included respondents who had complications of diabetic foot ulcer, random blood glucose > 300 mg / dl, gout arthritis. Measurement of capillary refill time variables using fingertip emphasis observation. Measurement of random blood glucose variables using a glucose stick test.Data analysis using wilcoxon & mann whitney test was used to measure the capillary refill time variable. Independent & paired t-test was used to measure glucose variables. Interventions were given 3 times a week for 4 weeks. Result: In the CRT variable using the Mann-Whitney test showed a p value = 0.022 which means that there was an effect of foot exercises on the status of peripheral vascularization. On the blood glucose variable using paired t test showed p = 0.004, and independent t test showed p = 0.012 which means there is an influence of foot exercises on blood glucose levels. Discuss: Foot have been shown to increase Nitric Oxode Syntesis, arterial vasodilation, blood sugar burning which results in a decrease in blood sugar, oxygen affinity of hemoglobin, and blood viscosity. Conversely an increase in blood circulation, oxygen saturation, tissue perfusion, and immune system can prevent diabetic foot ulcers. In a preventive effort the health department, especially the puskesmas, should provide health promotion media through the provision of foot exercise exercises.

Leprosy disease is caused by Mycobacterium leprae which attacks the skin and peripheral nerves. Currently leprosy still remains a world problem. Leprosy patients should not experience severe structural and functional damage. The combination of the empowerment education, peer support can improve symptoms and signs of impairment, behavioral prevention defects. The objective of this study was describes empowerment education, peer support to behavior prevention of dissability. This study used true experimental randomized pre-post test control group design. The sampel was recruited using simple random sampling consisting of 16 respondents. The independent variable are empowerment education, peer support. The dependent variable are knowledge of disability prevention, attitude of disaility prevention, action of medication compliance. The data were collected by distributing questionnaires and check card patient treatment. Data were analized by Mann-Whitney Test and Wilcoxon Signed ranked Test. The result showed that 1) There is influence on knowledge, 2) There is influence on attitude , 3) There is influence on medication adherence. Supportive interventions through empowerment education, peer support can help leprosy patients in the treatment process. Proven knowledge, attitude, adherence to medication, and self efficacy intervention group increased after given intervention. Suggestions for further research is to examine the development of leprosy impairment prevention models based on other nursing theories and with a longer duration of study.

Penyakit Diabetes Melitus membutuhkan perawatan kompleks dan waktu yang lama. Penyakit DM yang tidak diberikan manajemen pengelolaan dengan baik akan meningkatkan resiko munculnya komplikasi yang dapat mengancam pasien.  Berdasarkan data dari WHO diperkirakan jumlah pasien DM pada Tahun 2000 meningkat dari 8,4 juta menjadi 21,3 juta pada Tahun 2023. Lidah buaya dianggap obat antidiabetes karena memiliki beberapa zat kimia yang mempunyai sifat hipoglikemik seperti kromium, dan alprogen. Tujuan penelitian adalah mengetahui perbedaan efektifitas dua dosis ekstrak lidah buaya terhadap glukosa darah tikus diabetes mellitus yang diiunduksi streptozotocin. Desain penelitian true experimental randomized pre-post test control group design. Teknik sampling memakai simple random sampling yang terdiri 18 ekor tikus galur wistar, dan dibagi kedalam 3 kelompok yaitu kelompok kontrol yang diberikan intervensi berupa placebo, kelompok perlakuan 1 yang diberikan ekstrak lidah buaya dengan dosis 1x350 mg/dl, kelompok 2 yang diberikan ekstrak lidah buaya dosis dosis 2x350 mg/dl. Variabel independen adalah ekstrak lidah buaya. Variabel dependen adalah kadar glukosa darah. Intervensi pemberian ekstrak lidah buaya diberikan selama 10 hari. Data dianalisis dengan Paired t Test dan ANOVA. Hasil penelitian menunjukkan terdapat pengaruh ekstrak lidah buaya dosis 1x350 mg/kgBB melalui uji paired t test sebesar  0,001. Hasil penelitian menunjukkan terdapat pengaruh ekstrak lidah buaya dosis 2x350 mg/kgBB melalui uji paired t test sebesar  0,002. Hasil ANOVA menunjukkan ekstrak lidah buaya dosis 2x350 mg/kgBB memiliki efektifitas paling tinggi dengan p value 0.034. Hal ini membuktikan bahwa pemberian ekstrak lidah buaya sebesar 350 mg/kgBB sebanyak 2x sehari memberikan penurunan kadar glukosa yang signifikan.