The nematode Caenorhabditis elegans has risen as a critical creature show in different fields including neurobiology, formative science, and hereditary qualities. Qualities of this creature demonstrate that have added to its prosperity incorporate its hereditary manipulability, invariant and completely depicted formative program, all around portrayed genome, simplicity of support, short and productive life cycle, and little body estimate. These same elements have prompted to an expanding utilization of C. elegans in toxicology, both for robotic reviews and highthroughput screening approaches. We depict a portion of the exploration that has been completed in the territories of neurotoxicology, hereditary toxicology, and ecological toxicology, and additionally high-throughput tries different things with C. elegans including all inclusive screening for sub-atomic focuses of harmfulness and fast danger evaluation for new chemicals. We contend for an expanded part for C. elegans in supplementing other model frameworks in toxicological research.

Obesity is characterized as a health problem of high prevalence worldwide, and to date, about two thirds of the US population is affected, generating a high financial cost for health management systems. Traditionally, the model for the study of obesity has been rodents, mainly rats and mice, and although the obesity field has progressed a lot, there has been a clear need for a cheaper and more efficient model. C. elegans is a small worm with a life expectancy of about 21 days that possesses rapid growth and feeds on non-pathogenic strains of Escherichia coli. This small nematode has about 60 to 80 percent of its genes related to human diseases, and it is now known to the scientific community that manipulating its genome can provide valuable information to define the pathophysiological aspects of obesity. C. elegans has been successfully reported as an animal model in research related to nutritional physiology, in addition to the characterization of several metabolic pathways, storage mechanisms and lipid release. In recent years, due to the advances of C. elegans in the physiological characterization of lipid metabolism, it is now possible with its use as an animal model to offer the possibility of in vivo identification of compounds that modulate fat storage.