We have proposed a cooperative quinolone-DNA binding model for the inhibition of DNA gyrase. The essential feature of the model is that bound gyrase induces a specific quinolone binding site in the relaxed DNA substrate in the presence of ATP. The binding affinity and specificity are derived from two unique and equally important functional features: the specific conformation of the proposed single-stranded DNA pocket induced by the enzyme and the unique self-association phenomenon (from which the cooperativity is derived) of the drug molecules to fit the binding pocket with a high degree of flexibility. Supporting evidence for and implications of this model are provided.

The impacts on the Australian coast of a changing climate include environmental and property damage arising from increased frequency and severity of coastal weather events, storm surge, coastal erosion, and coastal flooding. Coastal management policies and planning laws are often relied upon to manage both the impacts and competing interests in the coast. The existence of these policies and laws, and their interpretation by the courts, bears a weight of expectation upon them to deliver in the face of climate change which merits further consideration. Indeed, a rich field is open from which to consider the constitution and construction of law in and across different places, in the context of climate change adaptation. The Australian coast is a unique and locally specific context from which to explore the relationship between law and place as performed in the Vaughan litigation, and this paper considers such important potential as it gains expression in the Vaughan litigation.

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Societies are now squarely facing the risks of environmental and climatic change, and developed coastlines are ground zero. Climate change will cause damage to, or loss of, coastal property – property that, in most Western societies, is considered a high net value asset. This paper examines cultural ideas about private property and the complexities of using land use planning law as an enabler of climate change adaptation. It reports the findings of qualitative research that explores how residents living in coastal Australia respond to the risks to their property and to the places they live that are posed by sea level rise and other coastal climate change‐related risks. By reporting how residents experience their material coastal environment, and how they relate with and to ideas of “property” in a coastal environmental change context, this paper contributes to both coastal policy and to legal geography scholarship.