Les plans factoriels complets à deux niveaux permettent essentiellement de repérer les facteurs et les interactions influents.Ils ouvrent la voie à des plans complémentaires permettant une modélisation mathématique de la réponse dans le domaine d'étude.Le classeur « PlansComplets.xls » permet :1. de construire des plans factoriels complets 2 n pour 2≤n≤5 (onglet Plan). 2. de rentrer les réponses observées ou mesurées lors du plan (onglet Réponses). On peut analyser simultanément jusqu'à 5 réponses. 3. de choisir les coefficients du modèle polynomial postulé (onglet Coefficients). 4. d'examiner l'analyse de variance correspondant à chaque modèle (onglet Résultats). 5. d'obtenir aux points expérimentaux du plan les réponses calculées avec le modèle retenu (onglet Résultats). 6. d'observer le diagramme des résidus (onglet Résultats). 7. de calculer des réponses prévues en tous points du domaine d'étude (onglet Résultats). 8. de vérifier avec le diagramme de Pareto, le diagramme de Daniel, le diagramme des résidus et l'Anova que les facteurs et les interactions retenus sont significatifs (onglets Résultats et Diagrammes).Remarques :• Les cases possédant un triangle rouge en haut et à droite contiennent des commentaires destinés à vous aider. • Pour éviter de supprimer des formules par mégarde, les feuilles sont protégées (sans mot de passe).

In the present work, microencapsulation of the essential oil blend (clove + lemon peel + thyme) was successfully used to produce a product that can be used as food additives or in the pharmaceutical industry for the manufacture of a food supplement or so-called nutraceutical of plant origin. The characterization of the powder of the microcapsules made it possible to observe that the essential oil was successfully incorporated into the coating matrix. This was designed by the wall material, namely maltodextrin represented a barrier allowing the protection of the active principle, the control of its release and the property retention of the encapsulated essential oil for a long time. This powder of microcapsules of essential oil mixture can be successfully used for medical purposes to remedy certain pathologies, in particular for its antioxidant, antibacterial and anti-inflammatory properties.

Rosemary (Rosmarinus officinalis L.) is a plant with needle-shaped leaves. It is mainly found in Mediterranean regions (Algeria, Morocco and Tunisia). Rosemary essential oil (EO) has several therapeutic virtues that were widely studied. However, the use of this EO is restricted due to its sensitivity to oxidation. Nanoencapsulation based on EO and polymers has been developed as one of the promising techniques to overcome this limitation. In this study, the emphasis was on optimizing the extraction and formulation of a food additive based on rosemary EO. In fact, the results showed that rosemary EO extraction depended on the parameters of the extraction process, and the optimum heating temperature and extraction time were determined using an experimental design methodology. The parameters for extraction were chosen as follows: heating temperature of 250 °C and a hydrodistillation time of 180 min. This optimization revealed that the maximum oil yield can be obtained. Rosemary EO was characterized by a dominance of 1,8-cineole, camphor, α-pinene, borneol and camphene as well as by high antioxidant and antibacterial capacities with low acute toxicity. The obtained formulation of a stable rosemary EO powder can be used as a food additive in several industrial applications.

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