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Introduction: Loneliness is the most painful experience of all human experiences that leads to severe psychological and physical problems. Aim: The aim of this study was to investigate the relationship between social and emotional loneliness, fear of negative evaluation, thought Suppression, and mindfulness with mediating self-concealment in students of the Shahid Charmin University of Ahvaz. Method: The research design is correlational and structural equations. The study population included all students of Shahid Charmin University of Ahvaz in the academic year of 2016-2017, 200 of them were selected as the research sample and answered the Mindfulness Attention Awareness Scale (MAAS), White Bear Suppression Inventory (WBSI), the brief version of the fear of negative evaluation scale (FNES), the short version of the social and emotional loneliness scale (SELSA-S) and self-conceal scale (SCS). Data analysis was performed using AMOS and SPSS software version 20 and Pearson correlation, path analysis, and bootstrap statistical methods. Results: The fit indices of the model including RMSEA=0.01, NFI=0.99, CFI=0.99, IFI=0.99, AGFI=0.99, GFI=0.99, which indicate good fit the proposed model. All the indirect effects of fear of negative evaluation with mindfulness and thought Suppression and also social and emotional loneliness with mindfulness and thought Suppression with the mediation of selfconcealment became significant (p≤0.001). Conclusion: Mindfulness reduces social and emotional loneliness, the fear of negative evaluation, thought suppression and self-concealment by accepting feelings and thoughts.