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Background: Medicinal plants remain the mainstay for primary healthcare. The present study evaluated the effects of sub-acute administration of Ricinus communis fresh leaves’ methanolic extract on the histopathology and biochemistry of the liver and kidney in Swiss albino mice. Methods: 24 male and female mice were randomly assigned into four equal groups. Group I (control) received 5% tween 80 orally, while the treated groups; II, III and IV received oral Ricinus communis extract at 250mg/kg/day, 500mg/kg/day, and 1000 mg/kg/day for 28 consecutive days, respectively. Tissue processing, staining and biochemical analysis were used to assess the changes induced histopathologically and biochemically on the liver and kidney tissues. Results: Female treated mice showed significant weight changes while male treated mice showed no changes. Histopathological alterations in liver and kidney sections were observed both in male and female mice. Serum levels of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase showed significant changes in both sexes. There were no significant changes in serum creatinine at all doses and in both sexes Conclusion: Methanolic extracts of Ricinus communis fresh leaves had hepatotoxic and nephrotoxic effects. Key words: Histopathology; Ricinus communis; liver; kidney; biochemical