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Objectives: To study clinical presentation and to determine outcome of open Neural Tube Defects at ourrespected institution. We took a review of all cases of open neural tube defects seen at the Neurosurgery Unit of hospital in the last years to document their medical patterns, assess their neonatal outcome.Materials and Methods: This retrospective study included 74 patients, admitted to the Department ofNeurosurgery, D. G. Khan Medical College and Hospital, Dera Ghazi Khan. The procedure for history takingand clinical examination was completed to measure Folic Acid Intake in first trimester, ultra sound abdomen,pre-natal diagnosis, hydrocephalous, CSF leak from swelling, sphincter involvement, weakness of lower limb,previous baby affected, type & location of open neural tube defects along the cranio-vertebral axis. Spine X-rays,neurosonograms, MRIs were carried out to find associated irregularities and complications if exist.Results: Out of 74 children born with open neural tube defects, 9 (12%) mothers received antenatal care only, 7(9%) get folic acid regularly. Prenatal diagnosis was made in 11 (14.8%) mothers whose antenatal abdominalultrasound was done. The most common type of myelomeningocele was lumbosacral 58 (79%). Forty-four(59.4%) babies have hydrocephalous while five babies were microcephaly. Increased risk of rupturedmyelomeningocele was linked with vaginal delivery. Sphincter disturbance and limb paralysis was present in 35(47%) and 32 (43.7%) of babies respectively. The mortality was in 12% patients.Conclusion: We suggest that efforts should be made in this respect to prenatal diagnosis of such lesions to getbetter neonatal outcome

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