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Abstract-Crucial measurement of Chronic Obstructive Pulmonary Disease (COPD) relies extensively on the use of spirometry, "gold standard" for diagnosis of COPD. Impulse oscillometry system (IOS) is a non-volitional way to access the mechanical structure of the respiratory system. The goals of our study were to find out the sensitivity and specificity of the IOS in diagnosis of COPD patients, and investigate which IOS parameters are related to severity and airflow obstruction in Vietnamese COPD patients. The study contain twenty-two COPD patients (