BACKGROUND Neonates are uniquely susceptible to overwhelming bacterial infections. It is very essential to diagnose the sepsis in early phase and it is also important to rule out sepsis to prevent irrational use of antibiotics. Though blood culture is considered as gold standard, it is time consuming with limitation in preterm and has high false negative rates. For the same reason, several rapid haematological tests are done as part of sepsis screen for early diagnosis of neonatal sepsis. OBJECTIVE The study was done to establish the role of haematological parameters like Total Leucocyte Count (TLC), Absolute Neutrophil Count (ANC), Immature to Total Neutrophil ratio (I/T ratio), Platelet count, C-Reactive Protein (CRP), Micro-Erythrocyte Sedimentation Rate (m-ESR), either alone or in combination as reliable indicators of septicaemia in clinically suspected neonates. METHODS A prospective study of 100 neonates clinically suspected as having sepsis, who were admitted to NICU, Navodaya Medical College, Hospital and Research Centre, Raichur were included. The above haematological parameters were evaluated and statistically analysed. RESULTS Among 100 neonates, only 42 cases were positive for blood culture and were considered true positives. Haematological parameters like TLC, I/T ratio, CRP showed high sensitivity, specificity, positive predictive value and negative predictive value as individually or in combination. ANC and micro-ESR showed low sensitivity but high specificity. Results were promising when tests were done in combination using haematological scoring system. CONCLUSION Irrespective of blood culture-positivity, evaluation of haematological parameters aid in early diagnosis and provide a rational basis for therapy and management of neonatal sepsis.

Background: Hysterectomy is the most common surgery performed in gynaecological practice, sometimes considered a lifesaving procedure in women, which also improves the quality of life for women with certain uterine pathologies such as fibroids, endometriosis, uterine prolapse and various types of cancer. The diagnostic value of histopathological examination is well explained and enables determination of origin of a particular benign or malignant lesion and in the latter, where adjuvant treatment is dependent upon grade and extent of invasion of disease. Aims: To study the histomorphological spectrum of lesions of corpus uteri in hysterectomy specimens and their distribution in different age groups along with clinicopathological correlation. Materials and Methods: The present study comprised of 450 hysterectomy specimens with lesions in the corpus uteri, received in the Department of Pathology, Navodaya Medical College, Raichur, during 5 years from October 2012 to September 2017. All the specimens were subjected to histomorphological study and clinical correlation was made. Results: The commonest type of hysterectomy was abdominal hysterectomy (84%) with the peak age incidence in 5th decade (45.33%). Most common clinical diagnosis was fibroid uterus (45.55%) and pathological diagnosis was leiomyoma (59.33%) and malignancy being endometrial carcinoma (2.67%). Clinicopathological correlation was observed in 46% of cases, commonly among malignant lesions (87.5%), when compared to benign lesions of corpus uteri (65.16%). Conclusion: The study emphasizes on histomorphological evaluation of lesions in hysterectomy specimens and is mandatory as various benign and malignant conditions occur with increasing frequency and carries diagnostic and therapeutic significance and should be done in all cases for confirming the preoperative clinical diagnosis and thus ensuring a better postoperative outcome.

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Background:The causes of pancytopenia range from simp le, co mp letely treatable diseases to serious life-threatening conditions. A thorough evaluation of these cases is mandatory as it would benefit the patients to receive appropriate treatment. Objecti ves: Evaluation of etio-hematological and clin ical spectrum of pancytopenia. Settings and Design: A prospective study of two years (Jan 2016 -December 2017) was conducted on pancytopenic patients, attending Navodaya Medical Co llege, Hospital and Research Centre, Raichur, Karnataka. Material and Methods: Etio-hematological and clin ical evaluation was done considering the relevant biochemical and serological investigations. Results: A total number of 1368 of cases were diagnosed as pancytopenia. The patients' age ranged from 19 to 68 years and M: F ratio was 2.1:1. Most frequent clinical symptom was generalized weakness (90%) and least was bony pain (2%). Peripheral smear examination revealed predominantly macrocytic blood picture (47.9%). Bone marrow aspiration was performed in 444 cases (32.4%), among which Megaloblastic anaemia (Exclusive and Co mb ined with iron deficiency anemia) was the commonest (52.7%). Et iologies of pancytopenia in decreasing order of frequency included Megaloblastic anemia {935 cases (68.4%) -Exclusive type (713 cases; 52.2%) and Combined with iron deficiency anemia (222 cases;16.2%)z, followed by Dengue fever (141 cases;10.3%), Hypoplastic/Aplastic anemia [106 cases;7.8% (Drug induced -4 cases; 0.2%)], Septicemia (60 cases;4.5%), Leukemia (46 cases;3.25%), Ch ronic malaria (46 cases ;3.25%) and Myelodysplastic syndrome (34 cases; 2.5%). Conclusion: Keeping in mind varied et iologies of pancytopenia, thorough diagnostic evaluation is required to achieve better clinical outcome.

Sclerosing mesenteritis (SM) is a rare, chronic, benign fibrosing condition of small and large bowel mesentery, found incidentally in half of reported cases. This disease generally has an indolent course, eventually may present with significant morbidities and unusually, death. 1,2 Among the mesentery attached to small and large bowel, SM mainly affects that surrounding small intestine and only rarely the mesentery around the latter. Its etiology is unknown, while the pathogenesis is obscure and pathological characteristics of the disease are nonspecific. 3 Patients may have varied clinical manifestations and present with abdominal pain, fever, chylous ascites, abdominal mass, constipation, gastrointestinal bleeding or diarrhoea and in rare cases, with small bowel obstruction. As clinical presentations and imaging patterns are nonspecific, a proper coordination between radiologists, surgeons and pathologists is essential and only histopathological analysis, provides a sound diagnosis of SM masses. 1,2 As very few cases have been reported in literature, we hereby document a rare and interesting case of SM of small bowel in an elderly female.