Möbius syndrome is a rare congenital disorder presenting with facial diplegia and horizontal gaze disturbance. Patients can have additional cranial nerve palsies and musculoskeletal deformities. Neurofibromatosis Type 1 is an uncommon neurocutaneous disorder. The only plausible link between these two disorders is autosomal dominant pattern of inheritance. Simultaneous occurrence of these two uncommon disorders has not been yet reported in literature, and it is the first case report to the best of our knowledge.

Takayasu arteritis is a chronic systemic inflammatory disease that usualy affects the aorta, its primary branches and occasionaly the pulmonary and coronary arteries. The clinical manifestations vary considerably and are typicaly caused by limb or organ ischemia illness and fever. Occasionally, dyspnea and pedal edema can be the sole primary presentation of Takayasu’s arteritis.International Journal of Human and Health Sciences Vol. 03 No. 01 January’19. Page : 37-39

Introduction:Smoking is an independent risk factor for ischemic heart disease and acute myocardial infarction. Smoking raise both heart rate and blood pressure, thus increasing myocardial oxygen demand, moreover it also decreases the dimension of coronary vessel and coronary blood flow. Inferior wall Myocardial Infarction is consequence of disease in usually Right coronary artery, whereas anterior wall Myocardial Infarction is usually disease in left coronary artery. The aim of the study is to evaluate whether smoking influence the incidence of inferior wall MI (Right coronary artery). Study objective was to find out whether there was an association between smoking and inferior wall Myocardial Infarction and an early association of atherosclerosis and ischemic heart disease with smoking. Material and methods: 126 patients of ST ElevationMyocardial Infarction admitted from the outdoor patient department/ emergency department/ Cardiology OPD in MMIMSR, Mullana, Ambala, considered for study. Those who are willing to participate and fulfilling the inclusion and exclusion criteria.Result: In our study there was a high proportion of smoker in patient with inferior wall MI than other location of MI. Smokers were prone to get myocardial infarction at a younger age as compared to others. Mortality was higher in anterior wall MI as compared to Inferior wall MI. Anterior wall MI presented with more complications i.e. cardiogenic shock and arrhythmias. Conclusion:Smoking enhance the risk of inferior wall MI more than other MI. Smoking thus appear to adversely affect the Right coronary artery to greater extent than left coronary arterial circulation by mechanism yet to be explored. Smoking leads to ischemic heart disease at early age.

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Background: Myocardial Infarction is one of the leading cause of deaths & mortality worldwide. Echocardiography is the key investigation in cases of myocardial infarction and confirms the presence of regional wall motion abnormality, presence of left ventricular dysfunction and to assess ejection fraction, as left ventricular ejection fraction has both therapeutic and prognostic significance.