The bioactive compounds contributing to aroma and natural antimicrobial potential of oil from Dacryodes edulis seed can be harnessed in food industries as food preservatives. This study therefore, reveals the preservative effect and organoleptic property of meat and fish preserved with oil from D. edulis seed. Proximate and mineral analysis of oil were carried out using standard methods. Preservative quality of oil on fish and meat was investigated at 4°C and 37°C. Organoleptic property of preserved fish and meat was determined using trained panellists. Fat, protein, carbohydrates, crude fibre, ash and moisture content of oil from D. edulis seed are 55.7%, 18.7%, 10.8%, 7.1%, 4.6% and 3.1%, respectively. Potassium (106.5 µg/g) and phosphorous (102.5 µg/g) have the relatively highest values compared (p<0.05) to other minerals like zinc, iron, calcium, magnesium, and sodium. Better preservative property of oil was observed on fried fish and meat kept at 4°C with no microbial growth. The highest microbial load (3.95 × 106 cfu/g) occurred in fresh chicken coated with oil from D. edulis seed after 7 days of preservation. Fish and meat fried with oil from D. edulis seed were well accepted (9.00) than those fried with groundnut oil (3.50). Oil from D. edulis seed is an edible oil that can be utilized as alternative vegetable oil with natural preservatives and embedded nutrients.