The alpha/immediate early genes of herpes simplex virus are regulated by the specific assembly of a multiprotein enhancer complex containing the Oct-1 POU domain protein, the viral alpha-transinduction factor alpha TIF, (VP16, ICP25), and the C1 cellular factor. The C1 factor from mammalian cells is a heterogeneous but related set of polypeptides that interact directly with the alpha-transinduction factor to form a heteromeric protein complex. The isolation of cDNAs encoding the polypeptides of the C1 factor suggests that these proteins are proteolytic products of a novel precursor. The sequence of the amino termini of these polypeptide products indicate that the proteins are generated by site-specific cleavages within a reiterated 20-amino acid sequence. Although the C1 factor appears to be ubiquitously expressed, it is localized to subnuclear structures in specific cell types.

Findings from this study suggest ways in which holistic nurse researchers can strengthen study designs and thus improve the quality of scientific evidence available for application into practice and improve health outcomes.

Citation ABSTRACTA unique, progressive multidisciplinary simulation was developed for a pediatric end-of life experience. In order to prepare all participants, regardless of discipline, extensive pre-briefing and reflective debriefing was developed. The project included seven evolving pediatric simulations, each one with multiple disciplines participating, over a four-week period. Key components of the pre-briefing stages included learning about the topic of end-of-life, understanding the different inter-professional roles, teamwork, and feeling comfortable with the simulation environment. Reflective debriefing was carried out in small groups immediately after the simulation with objective feedback and affirmation of interdisciplinary teamwork, skills, and communication. A second culminating debriefing also occurred which offered the students the ability to pull their experiences together and reflect and compare their perceptions to those of an actual survivor of the same disease. This project revealed to faculty the importance of using multistaged pre-briefing and debriefing in a progressive multidisciplinary pediatric simulation.

CitationTwomey TC. Pediatricians and pediatric nurses in the delivery of culturally competent care: A scoping literature review to investigate progress and issues around culturally diverse care in paediatrics. Review ABSTRACTThe demographics in the United States are rapidly changing. In 2012, 47.2% of the children who lived in the United Stated were of color. However, three out of four physicians identified themselves as White non-Hispanic and approximately 83% of nurses are White, nonHispanic. The changing demographics and increasing diversity of the population has an impact on care and quality of care being delivered by pediatric healthcare providers to children and their families. In 2005, The Office of Minority Health reported that the main ingredient in closing the gap in health care disparities is cultural competency. This scoping literature review investigated how pediatricians and pediatric nurses were progressing with their delivery of culturally competent care. The studies in the review revealed that the delivery of culturally competent care by pediatric health care providers has been a slow and difficult process and that there are identified areas of improvement. Pediatricians, pediatric nurses, other pediatric health care providers and families whose children received health care services from these providers were participants in the studies reviewed. Health care providers reported that more cultural competence training and education was necessary. Families in several studies identified communication/linguistics and the provider's ability to be more open and aware as areas where more cultural education and training are needed.

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