Introduction: COVID-19 is an acute, severe respiratory syndrome caused by the SARS II-Cov-19; corona virus transmitted between people that spread from positive patients of covid-1 virus through contact with droplets. Date from the Health Service Municipality of Lautem, total positive COVID-19 cases from 22nd of March 2020 until December of 2021 was 184 cases of morbidity and 5 cases of mortality. Objective: to describe the level of community’s knowledge about efforts to prevent the transmission of COVID-19 and to identify the level of knowledge (know, understand and apply) and to know the relationship between the level of knowledge of the community in the Nanacuro sub-village, Municipality of Lautem. Method: descriptive quantitative with cross-sectional aproximation using non probability sample with type accidental sampling and use questionnaires instrument. Results: Based on the results of the descriptive analysis the level of community’s knowledge about efforts to prevent the transmission of COVID-19 showed level of good knowledge with 41.3%, sufficient knowledge with 46.8% and less knowledge with 11.9%. In statistical test Rankpearman correlation coefficient value or Pearson (p) = 0.000 means that less than the value 0.05 and the coefficient value correlated with the value 0.680. Conclusion: The level of knowledge (know, understanding and application) of the community on efforts to prevent the transmission of COVID-19 majority is sufficient 46.8%, unless there is a strong relationship between the level of knowledge with efforts to prevent the transmission of COVID-19.