Many clinical conditions should be considered in the differential diagnosis of life-threatening events in cystic fibrosis patients after a lung graft transplant. We report on a 17-year-old boy who underwent a lobectomy owing to an inflammatory endobronchial polyp complicated by massive airways bleeding 12 months after having had a bilateral sequential lung graft for cystic fibrosis. This unusual complication underscores the requirement for flexible bronchoscopy in patients with recurrent infection at any stage after transplant. Early diagnosis may prevent life-threatening complications.

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